DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and MMEL1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	784	Identity:	295/784 - (37%)
Similarity:	439/784 - (55%)	Gaps:	65/784 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSG 81
            |..:.||:||:::....       ||.|   |....:...|..:.|.:.:.|.|..   ::.:..
Human    35 LVTAALVALGVLYADRR-------GKQL---PRLASRLCFLQEERTFVKRKPRGIP---EAQEVS 86

  Fly    82 DVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLK 146
            :||.|..|:..|:.:|:.|.|..||||:||:||||.:|....||:.....|.|.|:.|:|:..||
Human    87 EVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILK 151

  Fly   147 DII---TA-ERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADD 207
            .::   || :||..|.     ...||::|||:::||..|.:|:..:.|.:|||| :..|.||...
Human   152 AVLENSTAKDRPAVEK-----ARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWP-VAMDRWNETV 210

  Fly   208 SWTWQ-EQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYLVK-GFNETLVT 269
            ...|: |:......:.|:...:||..|..|.|||::.:|.:||.:|.: ||||... |.|..:..
Human   211 GLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVRE 275

  Fly   270 AYYKYMVDIAVLF--GAN--RD--LAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQL 328
            ||.::||.:|.|.  .||  ||  |.:.:::..||.|..||..:.|.|:|.:...||:.....:|
Human   276 AYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEEL 340

  Fly   329 QAAYPY--VQWVDYMNA--------LLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANY 383
            |:.:..  ..|..::..        |||      ::|::...:| :.::|..::.....|.|.||
Human   341 QSQFGLKGFNWTLFIQTVLSSVKIKLLP------DEEVVVYGIP-YLQNLENIIDTYSARTIQNY 398

  Fly   384 MFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVG 448
            :.||:....:|.||:.|:..::.|..||.|...:|.||:|||....|:|:.           :||
Human   399 LVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMEN-----------AVG 452

  Fly   449 SLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLD- 512
            ||||.:.|..|||:...|:::::|.||.:.|||:.|||.::||:|:.|..|:...||:||.:|:
Human   453 SLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEE 517

  Fly   513 -NEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLEN 576
             |.:|...|:.|:...|.|||:.|.....|...|..|||..|:...|:..|  |:||||||...|
Human   518 MNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGA--AVVNAFYSPNRN 580

  Fly   577 SIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYL 641
            .|.|||||||..||:.::|:.:|||.||.||||||||||||.||.||..||:.|||...:.:.:.
Human   581 QIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFR 645

  Fly   642 AKAKCIIEQYGNYT-ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYT 705
            .:::|:|.|||||: :.|...|:||.||.||||||||||:::|.||.:|..:.|.:.:|||||.|
Human   646 EQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLT 710

  Fly   706 PEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQK 770
            .||:|::...|.||..||.|.....|.|.||||.::||||||.|:..||..|||..|:||:|.::
Human   711 HEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKER 775

  Fly   771 CEVW 774
            |.||
Human   776 CRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	271/693 (39%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	275/702 (39%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	270/691 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830