Protein Alignment Nep2 and ece1

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001071260.3
• Gene: ece1 / 777750
• ZFINID: ZDB-GENE-061110-100
• Length: 766
• Species: Danio rerio
• Alignment Length: 782
• Identity: 261/782 - (33%)
• Similarity: 415/782 - (53%)
• Gaps: 88/782 - (11%)

  Fly    11 WRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKG 75
            |..:...|:.|:|      :|.|....|:|..|          :..||                .
Zfish    55 WAEKTHSERKLVV------LVCALSVALFICIV----------SLGLH----------------Y 87

  Fly    76 KSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDK 140
            |....| :||::.|:..||.||..:...|:||.:||.||||.::.:..:|:.|.....||.:.:.
Zfish    88 KESHPG-LCLSEPCVSVASAVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEH 151

  Fly   141 LQEQLKDII------TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIK 199
            ....:|:::      :..|.|.:.:.:      |:||||::.||.||.:|:..:..:.|||.| |
Zfish   152 NMAVMKNLLENTSMKSLSRAEQKAQWY------YQACMNESKIEELGAKPLQDLINQTGGWGL-K 209

  Fly   200 GDSWNADDSWTWQEQVK----KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-Y 258
            | .|..|:   :||.::    .|||:.|...:     :..|.::|...:|.:|||.|.| ||| |
Zfish   210 G-PWEKDN---FQEVLRIVSANFRTSPFFTVF-----VSTDSKSSNSNIIQVDQSGLGLPSREYY 265

  Fly   259 LVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLR 323
            |.|..||..:.||..::|::.||.|.::|.::..:...::||..||||:.|..:||:..::|...
Zfish   266 LNKTANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIKFETTLANITVPQVERRDEEKIYYKI 330

  Fly   324 TPAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWR 387
            ...:|....|.:.|:.:::::. |..||  :.|.:.:....:.:.:.:|::.|.|.|:.|||..:
Zfish   331 QAKELATLAPAIDWMPFLSSVFAPVELN--DSEPVVVYAKEYLQKVSELISNTNKSVLNNYMIMK 393

  Fly   388 IHGFSVGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDS-LGISVGSL 450
            :....|..|.::|:..:.::...:.|.::. ..|||.||            .|.|| ||.::|:|
Zfish   394 VVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCV------------SDTDSALGFALGAL 446

  Fly   451 YVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEK 515
            :|...|.:||||...:||:||:..|.|.|..|:|||.:|||.||.|..::...:|||..:::.::
Zfish   447 FVKATFSEDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKE 511

  Fly   516 LAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQF 580
            |...:...|:..|.||::.:....|....:.::||...|:..|  ...|..|||:|:..:|.:..
Zfish   512 LDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQW--SMTPPTVNAYYNPTKNEMVL 574

  Fly   581 PAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAK 645
            ||||.|..|:|...||.||||.||.|:|||:||.||||||::|..|||..||...:.:|:..:.:
Zfish   575 PAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQ 639

  Fly   646 CIIEQYGNYTERATGLN---LNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPE 707
            |::|||.||:     :|   |||.:|.|||||||||:..:|.||..|.:|:|.||.||.|.....
Zfish   640 CMVEQYSNYS-----INNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNH 699

  Fly   708 QMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCE 772
            |:|:|...|.||:....||....:.|..||||.|||:|::||..:|::.|.|...|||||.:|||
Zfish   700 QLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCE 764

  Fly   773 VW 774
            :|
Zfish   765 LW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	238/685 (35%)
ece1	NP_001071260.3	None