DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	251/774 - (32%)
Similarity:	406/774 - (52%)	Gaps:	58/774 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTA 72
            |.|.||...|...|:.:.|:. .:||....|   |.|                         |..
  Rat    53 PRWNRREVCLLSGLVFAAGLC-AILAAMLAL---KYL-------------------------GPG 88

  Fly    73 SKGKSGDSGDVCLTQECIHTASTVL-RKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSV 136
            :.|..|...:.|..::....|:..| ..:...::||.:||.||||.:|....|||||::..|.:.
  Rat    89 AAGTGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAA 153

  Fly   137 ISDKLQEQLKDIITAERPETEP--KHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIK 199
            |.::.:|:|:.::.  ||...|  ...|.....:::|::...||.|||.|:..|.|..|||.|
  Rat   154 IGEQNEERLRRLLA--RPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDL-- 214

  Fly   200 GDSWNADDSWTWQEQVKKFRTAG-FSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSRE--YLVK 261
            |.:.:...:..|......::..| :|...:...::.:|.:||::.:|.:||..|.|...  ||.:
  Rat   215 GGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQ 279

  Fly   262 G-FNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTP 325
            . .:|.::.||..:|..:..|.||:....|.:.:|.||..:|..::|..::.||:.|.:||..|.
  Rat   280 DEESEKVLAAYKVFMERLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSVYNKVTL 344

  Fly   326 AQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHG 390
            .|||...|::||...::.:..|  :.:|:|.:.|....:.:.:.:|:..||:|::.||:.||:..
  Rat   345 GQLQKITPHLQWKWLLDQIFQE--DFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVV 407

  Fly   391 FSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKH 455
            .....||..||:...:.|..:.|..:.:...:.|:..|..           ..|:::|:|:|.:|
  Rat   408 VLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANR-----------HFGMALGALFVHEH 461

  Fly   456 FHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYY 520
            |...|||...::|.:|:.:....|:|::||||:||..|:.||..|...:||||.:|..|.:...|
  Rat   462 FSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEY 526

  Fly   521 AKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGIL 585
             :.::....||::.|....|....|..|:|..|:|:.|:  ..|..:||:|...:|.:.||||||
  Rat   527 -EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWL--LPPQALNAYYLPNKNQMVFPAGIL 588

  Fly   586 QGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQ 650
            |...::...|:.:|:|.||.:||||:|||:||.|.|:|..|||..||...:...:|.||:||:..
  Rat   589 QPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRL 653

  Fly   651 YGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAG 715
            |.|:|  .....:||.:|.||||||.||:|.:|.||::|..:||||..|..|.||..|:|::|..
  Rat   654 YDNFT--VYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFA 716

  Fly   716 QTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |.||.|.|.:|:.:::.|..|:|..:|||||:|..::|.:.||||:.||||||.||.||
  Rat   717 QNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	230/673 (34%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	230/673 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830