DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and mmel1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	784	Identity:	277/784 - (35%)
Similarity:	433/784 - (55%)	Gaps:	55/784 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEKS--------LLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTAS 73
            :|||        .:|.:|:..:||.....|....||.||        ||. :...||.     :|
Zfish    11 MEKSTKPRKHRWTVVEIGLSVIVLLMSCALAGLIVLYTS--------ALR-ERFNIND-----SS 61

  Fly    74 KG---KSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFS 135
            ||   :|....:||.|.:|:..|:.:|:.|.|.|:||.|||::|||.::|...||:.....|.|:
Zfish    62 KGLKYRSDADSNVCTTPQCVTAAARLLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFN 126

  Fly   136 VISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKG 200
            ::.|:|:..||.::..|..: :.:.|:....||.:|||:.|||....:|:.|:.:.:|.|| :..
Zfish   127 ILRDELEIVLKGVLEMENKD-DREAFKKAKTLYSSCMNEILIEQRDSQPLLRLIDSIGDWP-VAS 189

  Fly   201 DSWNADDSWTWQ-EQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYLVKGF 263
            :.||.....||. |.........::...:::..:..|.::|::.:|.:||.:|.: ||:|.:...
Zfish   190 EVWNGTSEQTWSLEDTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDG 254

  Fly   264 NETLV-TAYYKYMVDIAVLFGANRDLAKTE------LLLSLEFEMALANISWPNEKRRNSSELYN 321
            |...| .||.::||.:|.:...:|:|.:.|      :...||.|..:||.:.|.|:|.:.:.|||
Zfish   255 NYKKVREAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYN 319

  Fly   322 LRTPAQLQAAYPY--VQWVDYMNALLPE-GLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANY 383
            ..|..:.|..:..  ..|..|:..::.. .::|..||.|.:....:.|.|.::|:|...|.:.||
Zfish   320 KMTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQNY 384

  Fly   384 MFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVG 448
            :.|.:....|..:|..|:..:..|..||.|...:||||::||.....:|:.           :||
Zfish   385 LVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMEN-----------AVG 438

  Fly   449 SLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEML-- 511
            :|||.:.|..:||....|::.:|:..:.:.|:|::|||.::|.:|:.|..:::..|||||.:|
Zfish   439 ALYVRETFSGNSKRMVGELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQIGYPDHILEE 503

  Fly   512 DNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLEN 576
            :|:||...||.|:...:.|||:.|............|||.||:...|:..|  |:||||||...|
Zfish   504 ENKKLDQEYAHLNFSEENYFENILENLAASAQKGHKKLREPVDPDMWIIGA--AVVNAFYSHNRN 566

  Fly   577 SIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYL 641
            .|.|||||||..||:.::.:.:|||.||.||||||||||||.||.||..||:.:||...:.:.:.
Zfish   567 QIVFPAGILQPPFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFE 631

  Fly   642 AKAKCIIEQYGNYT-ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYT 705
            .::||::||||.:: :.|.|.|::||.|.||||||||||:::|.||.:|.|:.|.|.:|||||..
Zfish   632 DQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVEREGEEPRLPGLDMN 696

  Fly   706 PEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQK 770
            .:|:|::...|.||...|.|.....|.|..|||.|:||||||.|.:.|::.|||..|:||||.:|
Zfish   697 HKQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEK 761

  Fly   771 CEVW 774
            |.||
Zfish   762 CRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	246/682 (36%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	250/691 (36%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	246/682 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930