DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and PHEX

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	727	Identity:	246/727 - (33%)
Similarity:	390/727 - (53%)	Gaps:	63/727 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLK 146
            :.||..|||..|:.:|.|:...|:|||||:.|||..::....||:|..|...:..:...:..:||
Human    52 EYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLK 116

  Fly   147 DII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLG-GWPLIKGDSWNADD 207
            :::   .:.|.:||.  .:...:||.:|||:..||....:|:..:..... .||:::.   |...
Human   117 ELLEKSISRRRDTEA--IQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLES---NIGP 176

  Fly   208 SWTWQEQ-------VKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQS--SLALSREYL---- 259
            ...|.|:       :..|| ..:|....|...:..|.:.|.:.::.|||:  |||:..:||
Human   177 EGVWSERKFSLLQTLATFR-GQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNST 240

  Fly   260 -VKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLR 323
             .|.:.:.|    ||:|||.|||.|||...|:.::...|..|:.:|.|..|:| .|.|..:||..
Human   241 EAKSYRDAL----YKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHE-NRTSEAMYNKM 300

  Fly   324 TPAQLQAAYPYVQWVDYM-----NALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANY 383
            ..::|.|..|...|:.|:     ..|.|...:::..|.:.:.||.:|:||.::|....|:.||||
Human   301 NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANY 365

  Fly   384 MFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVG 448
            :.||:....:..||..|:.|.|:::..:.|......:|.:||:...|::..|           ||
Human   366 LVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYV-----------VG 419

  Fly   449 SLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVN-WMDAKTKKEAKLKLHSMATHIGYPDEMLD 512
            .::|..:|.:|.|....|:|..:|..|.|:|::.| ||||.||::||.|..::...:|||:.:::
Human   420 KMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMN 484

  Fly   513 ----NEKLAAY-YAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYS 572
                ||.|.|. :::.|     ||.:.|....:.....|..||..|.||:|  ...|..||||||
Human   485 DTHVNEDLKAIKFSEAD-----YFGNVLQTRKYLAQSDFFWLRKAVPKTEW--FTNPTTVNAFYS 542

  Fly   573 SLENSIQFPAGILQGHFF-NAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDT 636
            :..|.|:||||.||..|| ..:.|:.:::||||.::|||.|||||:.||::|..|||..||..::
Human   543 ASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTES 607

  Fly   637 QKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWA--EKHG-PEAK 698
            ::.:..|.||:|.||.||..:..|||:.|..|.|||||||||::|::.|||:|.  .:.| .|..
Human   608 EEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPL 672

  Fly   699 LPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGS 763
            |||:.:|..|:|:::.....|..||.|:.:.::..|.|||.:|||.|::||.::|.|.|:||..|
Human   673 LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNS 737

  Fly   764 PMN-PVQKCEVW 774
            .|| .:..|.:|
Human   738 TMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	236/701 (34%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	236/701 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930