Protein Alignment Nep2 and Nepl21

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 734
• Identity: 202/734 - (27%)
• Similarity: 336/734 - (45%)
• Gaps: 112/734 - (15%)

  Fly    82 DVCLTQECIHTAST--VLRKMKPEVEPCDNFYEFACGTYLE-EENIPDDKVSISTFSVISDKLQE 143
            |....:|.:..|.|  :...|..:.:||::||.|:||.|.. ...:....|:...|..::..|..
  Fly    39 DTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNR 103

  Fly   144 QLKDIITA-----ERPE-TEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDS 202
            ::..::..     :.|| .:.|||      |::|:....:.:...|.:.|:....|..||::|.|
  Fly   104 KILKMLNTPHDSHDTPEDIKVKHF------YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSS 162

  Fly   203 WNADDSWTWQEQVKKFRTAGFSMDY----IIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYLVKG 262
            |..|| :.|..     .||..:..|    |....:..||.::|:..|.|.|....| :|...|..
  Fly   163 WQEDD-FDWLN-----TTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDD 221

  Fly   263 FNETLVTAYY--KYMVDIAVL----FGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYN 321
                 .||.|  ||..:|..:    .|...||||......::||:.||.......:..:..||..
  Fly   222 -----ATAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQ 281

  Fly   322 LRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSV----PSFFEDLGKLLAKTPKRVIAN 382
            |.|..::|..|.....:|.:       |.|:..|.|:..:    ..:.::|.:::.:||||.:||
  Fly   282 LLTVDEIQRRYSPTLDIDRL-------LFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVAN 339

  Fly   383 YMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISV 447
            |:|:|        |..||.:         :.....|.:.|.|||:......:           ::
  Fly   340 YIFFR--------LIWEFVE---------TPSDSPEKQMKACVDLTKKYFAK-----------NL 376

  Fly   448 GSLYVGKHFHKDSKANALEMVNEIRNVFNDIL---DEVNWMDAKTKKEAKLKLHSMATHI-GYPD 508
            .:::..::.::.|......|..::::.||:.|   ..:||::..|:..|..||.:|...: .|.|
  Fly   377 DNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYAD 441

  Fly   509 EMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYS- 572
            :....|     :|:|::..|.|.|:....::.|.......|..|         |:|....:..|
  Fly   442 DNFTEE-----FAELNLQSDDYVENVRYTSLLGAKQMREMLHKP---------AKPFEAGSQLSY 492

  Fly   573 -----SLENSIQFPAGILQG-HFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDW 631
                 .:||:|:.|..:||. :.::...|..:.||.:..:||||:.|||||.||:||.|||.:||
  Fly   493 TPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDW 557

  Fly   632 WHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEK---- 692
            |...:...:|.:..|..:|||.|.  ..|:.|.....|.||||||||::.:|.|||:|.|.
  Fly   558 WDEKSSSNFLKRRDCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTL 620

  Fly   693 -HGPE----AKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKD 752
             :|.:    ..||.|.||.:|:|:::..|:||.........::::|..|.|..|||:|||||.::
  Fly   621 PNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEE 685

  Fly   753 FAKDFHCPEGSPMNPVQKC 771
            |:|:|:||.||.|||.:||
  Fly   686 FSKEFNCPAGSAMNPSEKC 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	197/710 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:341056	195/708 (28%)