Protein Alignment Nep2 and Nepl20

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 789
• Identity: 211/789 - (26%)
• Similarity: 354/789 - (44%)
• Gaps: 150/789 - (19%)

  Fly    36 FGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIH--------T 92
            |.:||               |.|..|..:...||          |.|| |.|:..:        .
  Fly     6 FCIWI---------------ASHVLSVLVLAAPT----------SEDV-LNQDTPYMKELMRQAK 44

  Fly    93 ASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKV-SISTFSVISDKLQEQLKDIITA----- 151
            |:.:...|..:|:||.:||.|:||.|....:..:.:| :...|..::..|..::..::..
  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSH 109

  Fly   152 ERPE-TEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQV 215
            :.|| .:.|||      |::|:....:.:...|.:.|:....|..||::|.||..|| :.|..
  Fly   110 DTPEDIQVKHF------YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDD-FDWLN-- 165

  Fly   216 KKFRTAGFSMDY----IIDFSIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYK--Y 274
               .||..:..|    ||...:..|..|:.|.:|.::|....|....:... ||   ||.|:  |
  Fly   166 ---TTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMD-NE---TAIYRQNY 223

  Fly   275 MVDIAVL----FGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYV 335
            ..:|.::    .|...:||:.......|||:.||:....|.|..|..:|..|.|.|:|:..|...
  Fly   224 QNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPT 288

  Fly   336 QWVDYMNALLPEGLNVAEDEMINLSV----PSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFL 396
            ...|.:       :.|:..|.|:..|    ..:.::|.:::.:|||..:|||:|.|        |
  Fly   289 LDTDQL-------IFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLR--------L 338

  Fly   397 SEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSK 461
            ..||.::.       ||..|:..  :.|||...:...:           ::.::...::.::.|.
  Fly   339 IWEFIQKP-------SGVAEKPT--EACVDFTKTYFAK-----------NLDNMIYRRYKNEKSS 383

  Fly   462 ANALEMVNEIRNVFNDIL---DEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKL 523
            .....|.:::::.|.:.|   ..::|::..|:..|..||.:|...:.             .|.|
  Fly   384 REIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN-------------NYVK- 434

  Fly   524 DIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRH-----ARPAIVNAFYS------SLENS 577
                :.:.|.|..:|:..||...|..::.:.:...:|.     |:|.......|      .||||
  Fly   435 ----ENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENS 495

  Fly   578 IQFPAGILQG-HFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYL 641
            |:.|..:||. :.::...|..:.||.:.|:||||:.|||||.||:||.|||.:|||...:...:|
  Fly   496 IKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFL 560

  Fly   642 AKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEK-----HGPE----A 697
            .:..|..:|||.|.  ..|:.|.....|.||||||||::.:|.|||:|.|.     :|.:    .
  Fly   561 KRRDCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKE 623

  Fly   698 KLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEG 762
            .||.|.||.:|:|:::..|:||.....:...::::|..|.|.:|||:|:|||.::|:|:|:|..|
  Fly   624 TLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAG 688

  Fly   763 SPMNPVQKC 771
            |.|||::||
  Fly   689 SAMNPIEKC 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	196/713 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:341056	194/711 (27%)