Protein Alignment Nep2 and Nepl18

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 748
• Identity: 183/748 - (24%)
• Similarity: 321/748 - (42%)
• Gaps: 135/748 - (18%)

  Fly    76 KSGDSGD------------VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDD- 127
            |..|:||            ..:.|..:....|:   |||||.|||:||..|||.:  ..:.|..
  Fly    21 KPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTM---MKPEVSPCDDFYTHACGNW--HRHNPAQL 80

  Fly   128 --KVSISTFSVISDKLQEQLKDIITAE--RPETEPKHFRL---PNLLYKACMNKTLIETLGPEPI 185
              .|....|.:||.....:|:.::.|.  :.|.|.|..|.   .||:::..::..|       .:
  Fly    81 LGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFYMSCNLVHRDDVHYKL-------AL 138

  Fly   186 TRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQS 250
            ..|....|..|.:.|..||:.| ::|...|.:.:.. :....||...|..|::|:
  Fly   139 ENVIREYGTLPALVGAQWNSSD-FSWWRTVAQIQHK-YGKQIIIGLEIMHDIRNT---------- 191

  Fly   251 SLALSREYLVKGFNETLVTAYYKYM------VDIAVLFGANRDLAK--TELLLSLEFEMALANIS 307
              :::|.|:.:...:|:.|.....|      :|:...||.:..:||  .|.|..||     ...|
  Fly   192 --SVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQLTELE-----RTFS 249

  Fly   308 WPNEKRRNSSELYNLRTPAQLQAAY-PYVQWVDYMNALL-----PEGLNVAEDEMINLSVPSFFE 366
            ..........|..:|.|.|.||..| .::.:.:::..:|     |:.|.:.::|.::.::.:
  Fly   250 SGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLILGEENIPKSLYIYDEEYLDKALLT--- 311

  Fly   367 DLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSS 431
                 :..||....|||:.|:        |.|:|         .:..:.:...:|  |.:.....
  Fly   312 -----MRSTPLATQANYVLWK--------LLEDF---------LVDAQPKDMVKW--CTESTKKY 352

  Fly   432 MDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDIL--DEVNWMDAKTKKEAK 494
            ..::.|.          ::| .::.:.|.::...::.::|:.:|...|  |:::|:...|:..|.
  Fly   353 FGKLAEH----------AVY-KRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAI 406

  Fly   495 LKLHSMATHI-GYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDW 558
            .||..|..:| .|.:|..:|     .|.::.||...|..:...:.|........::..|.:..|.
  Fly   407 EKLERMHLNINSYDEENFEN-----VYGEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDA 466

  Fly   559 VR--HARPAIVNAFYSSLENSIQFPAGILQ-GHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGR 620
            ..  ...||     |:..||:|..|..:|| .:|:..|.|:.:.:..:||::.||:.|||||.||
  Fly   467 TELLGFTPA-----YNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGR 526

  Fly   621 QFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIA 685
            |:|..|||..||...::..:..:.||...||..|  :..|..|.....|.|||||:||:|.:|.|
  Fly   527 QYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEY--QYGGSKLPESKDQSENIADSGGLKLAYAA 589

  Fly   686 YRRWAEKHGPEA----KLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGV-----HSPSEF 741
            |..|..:...|.    .:.||.:...|:|::...|..|     :.::......|     |:||::
  Fly   590 YELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLC-----DDVQFLFQPWVSQSDRHAPSKY 649

  Fly   742 RVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ||:|.|||.::|...|:|.:.:||:|..||.::
  Fly   650 RVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	172/704 (24%)
Nepl18	NP_651643.1	M13	58..679	CDD:341056	171/703 (24%)