Protein Alignment Nep2 and Nepl15

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 155/709 - (21%)
• Similarity: 282/709 - (39%)
• Gaps: 116/709 - (16%)

  Fly   105 EPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYK 169
            :.|:|||.:||..:.........|...:....:.:....:..|::.:.....|....|.....|.
  Fly    55 QACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYG 119

  Fly   170 ACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIG 234
            :|..:|.........:..|.:..||||.|:..||...: :.|.:.|...:.. ..:|..|...:.
  Fly   120 SCRLQTNDTRSALNTLQNVTDFRGGWPEIRVASWYQYE-YDWLQVVANLKRK-LGVDIFIGLEVI 182

  Fly   235 VDLQNSTKRLIDLDQSSLALS-REYLVKGFNETLVTAYYKYMVD--IAVLFGANRDLAKTELLLS 296
            :|.:......:.:......:| |.||...|..|  ...|:..::  :.:.|....:..:.|:...
  Fly   183 LDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGT--REIYERSIENKLKLYFPEQSEHWRQEVASQ 245

  Fly   297 -LEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAY-PYVQWVDYMNALLPEGL-----NVAED 354
             ::.|..||. ..|:......::....||.|:::.|| .||....|:..:..:.|     ...||
  Fly   246 VVQIEQQLAK-GLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYETPED 309

  Fly   355 EMINLSVPSFFEDLGKLLAKTPKRVIANYMFWR-IHGFSVGFLSEEFRKRQLQYATALSGRQEQE 418
            .|.||.         .::.:|||..:|||..|: :....:                |.....::.
  Fly   310 YMSNLV---------DVIRETPKLQLANYTMWKALEALDI----------------ARVPASQRA 349

  Fly   419 ARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDI----- 478
            ..|  ||.:|    .:......:||            ||::  .|.::|:||:::.::||
  Fly   350 DIW--CVQLA----QQFFPHQLESL------------FHRN--YNHMQMINELQSTWSDIKRVFR 394

  Fly   479 -----LDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMN 538
                 .:.:.|:..:|:::|..||.::..|.    ...|:.||......|.::.|:::.:.:.:.
  Fly   395 EDLQASERLLWLTLETRQKAITKLEALKLHF----RTHDDNKLIRQMHGLILNMDRFYPNLVSVL 455

  Fly   539 IFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFF-NAQRPKYMNFGA 602
            .:.|.....||.......|.| |..|     .|...:|.||.|...||..|| :...|..:.:..
  Fly   456 QWKTQRGLAKLMTEPVAEDEV-HKLP-----HYEIQKNRIQVPITFLQARFFWDPAYPNGLKYAT 514

  Fly   603 IGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGIN 667
            :|.::..::.||||..||::|..|...:||...::.:|..:.:|..|||..:.|      ..|..
  Fly   515 LGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVE------YKGKP 573

  Fly   668 TQGEN-----IADNGGVKESYIAYRRWAEKHGPEA-------KLPGLDYTPEQMFWVAAGQTWCA 720
            .|.::     :||||.:..:|.||::|. |:..|.       :||.||:...|:|::...|.:|.
  Fly   574 VQDKDLLRRIVADNGALDIAYRAYQQWL-KNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCT 637

  Fly   721 KY-----RKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .|     |.:.|          |.:.||..:|||.:.||..:.|.....:|...||.::
  Fly   638 DYPETVERFDEL----------PEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	154/705 (22%)
Nepl15	NP_651098.2	M13	56..684	CDD:341056	154/704 (22%)