Protein Alignment Nep2 and Nepl14

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Alignment Length: 774
• Identity: 145/774 - (18%)
• Similarity: 275/774 - (35%)
• Gaps: 203/774 - (26%)

  Fly    90 IHTASTVLRKMKPE---------VEPCDNFYEFACGTY--------------------LEEENIP 125
            |:.:...:|:.|.:         ::||.:||.:|||.:                    |.||.:.
  Fly    37 IYQSEQTVRRSKAQDMGSHVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTDRELLLLVEEAVR 101

  Fly   126 DDKVSISTFSVISDKLQEQLKDIITAERPET-EPKHFRLPNLLYKACMNKTLIETLGPEPITRVA 189
            .:.      |||..:.:|..|..::|:..:: :.:||                       ::...
  Fly   102 RED------SVIVRQAKELFKSCVSAQAHQSQQQQHF-----------------------LSEFI 137

  Fly   190 ERLGGWPLIKGDSWNA-DDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLA 253
            .:.||:|.:.|..|.. ...:.|...:...|.. :.||.:|...:|.:..|..:..:.|.:.|..
  Fly   138 NQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLR-YGMDILIGLRVGYNYGNVNENSLYLSEPSTL 201

  Fly   254 LSREYLVKGFNETLVTAYYKYMVDIA------VLFGANRDLAKTELLLSLEFEM-----ALANIS 307
            :..|...:..::...:.|......:|      :..|.:........:||.|.|:     ..:..|
  Fly   202 IPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARLAADILSFEHELCGGMKGGSFES 266

  Fly   308 WPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEM---------------I 357
            |..|:     :||                ..:|....|.|..|..|.::               :
  Fly   267 WDAEE-----QLY----------------LANYTRKTLREFSNSIELDLDSYVRASFGQDIYKPV 310

  Fly   358 NLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWK 422
            .::.|.:|..|.:.::.....::|||:.:|    :|..|:.....|             .:.|.:
  Fly   311 YMAAPEYFRQLKRTVSAHNISLVANYIMYR----AVSALNFPLDDR-------------PQLRKR 358

  Fly   423 ECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDA 487
            ||:           |...:.|..::|.||..:...:|.:.:...:.:.::......|. ..|:..
  Fly   359 ECL-----------ERTKELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSLG-AEWLVE 411

  Fly   488 KTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRL- 551
            .|::..:.||.::..      :|...|:  ....||.::...|:::.  ..:.|...|....||
  Fly   412 GTQRVGQEKLRNLKL------QMPTYER--PVILKLQLERGNYWQNL--RQLLGVVQSQRNNRLF 466

  Fly   552 ---------PVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKY---MNFGAIG 604
                     ||...:.....||         ::..:.....:||...::   |:|   :.:..:|
  Fly   467 EEFLPAPTDPVEAYEARVRLRP---------VQRRLDMGLALLQPPAYD---PRYGHAIRYATLG 519

  Fly   605 YVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQ 669
            ..:..::...|||.  .:.|....||.|...|...|..::.|...|..||      |..| ::..
  Fly   520 VQLAQQLVMAFDDP--HWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNY------LRPN-VSAT 575

  Fly   670 GENIADNGGVKESYIAYRRWAEKHGP--------EAKLPGLDYTPEQMFWVAAGQTWCAKYRKES 726
            .:.|.|:..:..::.||..|.....|        :..||.|:|:...:|::|..|..|:   .|.
  Fly   576 TQLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCS---LEE 637

  Fly   727 LKMRITTGV-----------HSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .:.|...|.           |:.:...|.|.|.|..:||.:|.||.||||||..||.::
  Fly   638 ARPRDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	141/747 (19%)
Nepl14	NP_651097.1	M13	60..693	CDD:341056	140/746 (19%)