DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and Nep4

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	906	Identity:	287/906 - (31%)
Similarity:	445/906 - (49%)	Gaps:	174/906 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RNKLEKSLLVS---LGIMFVVLATGFGL-----------------------WIGKV----LRTSP 48
            ||.|.|....|   |||....|.:|..|                       |:.|:    .|.:.
  Fly   164 RNTLMKDSRTSFLPLGIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAE 228

  Fly    49 PSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEF 113
            ....:|:|...::|...|     :...:.|....:.:||     |.|:.|.|..:|:||.:||::
  Fly   229 RHAEEASAEISEATAALQ-----SFWNEEGTREGIRMTQ-----AKTMKRYMDNKVDPCVDFYKY 283

  Fly   114 ACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDI------------------------------ 148
            |||.:.....||.||....||.::.:.|...|:::
  Fly   284 ACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGE 348

  Fly   149 ----------ITAER-------------------------------------------------- 153
                      :||||
  Fly   349 GEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVL 413

  Fly   154 PETE-------------PKHFRLPNL--------LYKACMNKTLIETLGPEPITRVAERLGGWPL 197
            |:.:             |..|..|:.        ||::|:|..::...|.||:..:...|||||:
  Fly   414 PKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPV 478

  Fly   198 IKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYLVK 261
            :: ..| ::.::.||......|.  ::.|.:|...:|.|::||.:.::..||:.|.| :|||.::
  Fly   479 LE-SQW-SESNFNWQVLAATLRR--YNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQ 539

  Fly   262 GFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPA 326
            ..|...:.||.:||.::....||::..|:......:.||..||.|:.|.|:|.|.::||...|..
  Fly   540 PSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLD 604

  Fly   327 QLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGF 391
            ||||..|.::|..|:.:|  :...|...|.:.:....:...|..||.:|..|.::|||.||....
  Fly   605 QLQAVVPEIKWRAYLQSL--QDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRH 667

  Fly   392 SVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHF 456
            .:..:.:.|...:..:..||.||:|...|||.|:....::|           |::|||::|.::|
  Fly   668 RINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNM-----------GMAVGSMFVSRYF 721

  Fly   457 HKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYA 521
            ..:||.:.|.|.::::..|.|||...:|:|..||:.|:.|:::|:..|||||.:|:..:|.:.||
  Fly   722 DNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYA 786

  Fly   522 KLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQ 586
            .::|.|:||||:.|.:.:........||...||||:|  ...||||||:||..:|.|.|||||||
  Fly   787 GIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNW--QTAPAIVNAYYSRNKNQIMFPAGILQ 849

  Fly   587 GHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQY 651
            ..|::...||.:|||.||.|||||:||||||:||.||..||:..||...:.:.:..:|:|||.||
  Fly   850 PPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQY 914

  Fly   652 GNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAK---LPGLDYTPEQMFWVA 713
            .|||....|:.|||.:|||||||||||:::::.||:||.::|..|..   ||||:.|..|:|::.
  Fly   915 SNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLN 979

  Fly   714 AGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .||.||...|.|:::.::.|.:|||..|||:|:|||..|||::|:||.||||||.:||.||
  Fly   980 FGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	259/782 (33%)
Nep4	NP_650904.3	M13	274..1038	CDD:189000	259/782 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.830