DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Ece2

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	254/764 - (33%)
Similarity:	400/764 - (52%)	Gaps:	70/764 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVSLGIMFVVLATGFG----LWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGD 82
            ||..|::.|:.|...|    ||:               ..|.|..                  ..
  Rat   208 LVLAGLILVLAALLLGCLVALWV---------------QYHRDPV------------------HS 239

  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKD 147
            .|:|:.||..|..:|..:...|.||.:||:|:||.::....:|..:...:||:.:.|:.|..||.
  Rat   240 TCITEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKH 304

  Fly   148 IITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQ 212
            ::......:..:..|.....|.:|::...||.||.:|:..:.:::|||.:.  ..|:.|:   :.
  Rat   305 LLENSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNIT--GPWDEDN---FM 364

  Fly   213 EQVK----KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLVKGFNETLVTAY 271
            |.:|    .:|.|.|...|     :|.|.::|...:|.:|||.|.| ||: ||.:..||.::.||
  Rat   365 EVLKAVAGTYRAAPFFTVY-----VGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAY 424

  Fly   272 YKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQ 336
            ..|||::.:|.|......:.::...||.|:.||.|:.|.::||:..::|:..:.::||...|.:.
  Rat   425 LDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPSMD 489

  Fly   337 WVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFR 401
            |:::::.|| ..|.:.:.|.:.:....:.:.:.:|:.:|...::.||:.|.:...:...|.:.|.
  Rat   490 WLEFLSFLL-SPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFE 553

  Fly   402 KRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANAL 465
            ..|.:....|.|.::. ..||:.|:    |:.|       |:||.::|||:|...|.:.||..|.
  Rat   554 TAQEKLLETLYGTKKSCTPRWQTCI----SNTD-------DALGFALGSLFVKATFDRQSKEIAE 607

  Fly   466 EMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKY 530
            .|::|||..|.:.|:.:.|||.||:..||.|..::...||:||.:|:..:|...|...::..|.:
  Rat   608 GMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYDGYEVSEDSF 672

  Fly   531 FESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRP 595
            |::.|.:..|......::||.|.::..|  ...|..|||:|...:|.|.|||||||..|:....|
  Rat   673 FQNMLNLYNFSAKVMADQLRKPPSRDQW--SMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHP 735

  Fly   596 KYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATG 660
            |.:|||.||.|:|||:||.||||||::|.:||||.||..::..|:.....|:.|||..|  :..|
  Rat   736 KALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQY--QVNG 798

  Fly   661 LNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKE 725
            ..|||:.|.|||||||||:|.:|.||:.|..|||.|..||.:..|..|:|:|...|.||:....|
  Rat   799 ERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPE 863

  Fly   726 SLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |....:.|..|||:.|||||:|||.:||.:.|.||.||||||.|.||||
  Rat   864 SSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	234/674 (35%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	231/678 (34%)
		M13	261..910	CDD:189000	234/674 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830