DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and KEL

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	754	Identity:	176/754 - (23%)
Similarity:	296/754 - (39%)	Gaps:	161/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDI 148
            |.|..|:......|......|.||.:|:.||||...|..|         :|..::.|.:.:|:.|
Human    89 CETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNN---------SFQELATKNKNRLRRI 144

  Fly   149 ITAERP----ETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSW 209
            :..:..    ..|.|.|:    .|.:||:...||..|..|:.:|.|.||||.:        ...|
Human   145 LEVQNSWHPGSGEEKAFQ----FYNSCMDTLAIEAAGTGPLRQVIEELGGWRI--------SGKW 197

  Fly   210 TWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREYL--------------- 259
            |             |:::           |.|.||:..........|.||
Human   198 T-------------SLNF-----------NRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQID 238

  Fly   260 -------VKGFNETLVTA-----YYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEK 312
                   :|...|..:.|     |..|:..:..|.|.:....:....||:.....|.....|.|:
Human   239 QPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQ 303

  Fly   313 RRNSSELYNLRTPAQLQAAYPYVQWVDYMNA-LLPEGLNVAE-----------------DEMINL 359
            ||...:|:.:.|..||:...|.:.|:..:.| ..|..|:.::                 :||: |
Human   304 RRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEML-L 367

  Fly   360 SVPSFFED---LGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQ---- 417
            ....|.:.   ||.::..:|.                  |..:|::.:.:.:..|....||
Human   368 KQRDFLQSHMILGLVVTLSPA------------------LDSQFQEARRKLSQKLRELTEQPPMP 414

  Fly   418 -EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDE 481
             ..||.:||: .|.:..|.          ::.:|:|.:.|...:::.|:::...||:.....|..
Human   415 ARPRWMKCVE-ETGTFFEP----------TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRN 468

  Fly   482 VNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSF 546
            :.||:.:|:..|:.|:..:...:|..:..|..|.....|..:.:. ..:.:|.|.        ..
Human   469 LPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLS--------CV 524

  Fly   547 NKLRLPVNKTDWVRHAR------PAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGY 605
            ..||..:.::....|.:      |..|||:||..::.:.||||:||..||:...|:.:||||.|.
Human   525 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGS 589

  Fly   606 VIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQG 670
            ::.||:.|.|    .|..:.|......:...|:|:|    |:...|..: ...:..:.|...|..
Human   590 IMAHELLHIF----YQLLLPGGCLACDNHALQEAHL----CLKRHYAAF-PLPSRTSFNDSLTFL 645

  Fly   671 ENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGV 735
            ||.||.||:..:..||.:...:|..|..||.||.:|:|:|:.:..|..|.|...:.     :...
Human   646 ENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQD-----SHDT 705

  Fly   736 HSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |||...||.|.||:...||:.|.|..|:.:||..:|::|
Human   706 HSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	170/730 (23%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	171/735 (23%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	170/730 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920