Protein Alignment Nep2 and Nepl4

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 788
• Identity: 160/788 - (20%)
• Similarity: 263/788 - (33%)
• Gaps: 210/788 - (26%)

  Fly    54 ATALHGDSTTINQVPTGTASKGKSGDSGDVC-LTQECIHTAS-----TVLRKMKPEVEPCDNFYE 112
            |..|.|.:|..:.||.      |:.|....| ...||..|.:     |::..:..|..||::||.
  Fly     8 ALLLLGSATCGSSVPV------KANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYA 66

  Fly   113 FACGTYLEEENIPDDKVSISTFSVISD-KLQEQLKDII-----TAERPETEPKHFRLPNLLYKAC 171
            :|||.:..:..      |.:|.::||: ::..|.:|:.     ....||.....|......|::|
  Fly    67 YACGKWRAKHG------SHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSC 125

  Fly   172 MNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVD 236
            :      .|....:.|..|      |:..|...:.:|..|...:......|:...|:   .:.|.
  Fly   126 I------ALEKPDLRRYIE------LLDRDLLASLNSTHWMHLLAALGRYGYHGHYV---QVEVR 175

  Fly   237 LQNSTKRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEM 301
            ..|:|..:|                                  .|...||.|   .|.|:.:...
  Fly   176 WYNATHHMI----------------------------------FLLPHNRHL---NLSLTQDIYD 203

  Fly   302 ALA--NISWP------NEKRRNSSELYNLRTP------------AQLQAAYPYVQWVDYMNALLP 346
            ||:  ..|||      .:.|.....|..|..|            .|::...|.:.|.:.:...|
  Fly   204 ALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSADDTFRNYSLDQIRTEVPGLHWDEALRTQL- 267

  Fly   347 EGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATAL 411
             |.:|..:.:..:......|.|.:.|......::..|...|       |||..........||..
  Fly   268 -GRSVPGNHVFQVDDLDAIEGLVEYLNTVDTLLLNRYSLAR-------FLSHLLELPHNPLATWE 324

  Fly   412 SGRQEQEARWKECVDIATSS----MDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIR 472
            ||   |.:|.:.|:.....|    |:.|.|..|.|.......|.:...|.:      |:...|:|
  Fly   325 SG---QRSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQ------LQSQLELR 380

  Fly   473 ---NVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDK----- 529
               |.||...|.|        |..:.|:|.|..::|   .:..|.....|:     |.|:
  Fly   381 VQHNAFNLSQDLV--------KSLQAKVHQMRINVG---NLPPNVTEQFYW-----DSDRRWSVG 429

  Fly   530 --YFESFLGMNIF----------GTD-------YSFNKLRLPVNKTDWVRHARPAIVNA--FYSS 573
              ::|:.|...::          .:|       |||| :..|         ..|..::|  ::..
  Fly   430 RDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFN-MHTP---------EFPDNIDATPYFYC 484

  Fly   574 LENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQK 638
            |.|.|..|...::..||:|.....:.:|.:...:||||.|.||.....:|.:||||::      .
  Fly   485 LGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNF------S 543

  Fly   639 AYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIA--DNGGVKESYIAYRRWAEKHGPEAKLPG 701
            ..|.:.:......|.....|..||....:..|..:|  ..||         .|..:.|
  Fly   544 DQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYGG---------DWLTRSG------- 592

  Fly   702 LDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMN 766
                ..:::::.....:|.....:         .|.....|:..:|..:..||:.|.|..||.|.
  Fly   593 ----NGRLYFLQFAHFFCGDEGDQ---------YHDSGSQRLNYALGQVPQFAEVFRCHVGSGMT 644

  Fly   767 PVQKCEVW 774
            ...:|..|
  Fly   645 SADQCPFW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	144/728 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	144/726 (20%)