Protein Alignment Nep2 and Nepl3

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 130/613 - (21%)
• Similarity: 219/613 - (35%)
• Gaps: 148/613 - (24%)

  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKD 147
            ||.....:.....:|..|..:||||.|||           |.....:....|:.:||:.|.....
  Fly    21 VCSANPNLEIMKRMLDDMDEKVEPCHNFY-----------NSSQKNLKWHAFATVSDQFQLLFDG 74

  Fly   148 IITAERPETEPKHFRLPNL--LYKACMNKTLIETLGPEPITRVAERLGGWPLI--KGDSWNADDS 208
            |    ..|...||.....|  |||.|........|....:.:..|.| .||.:  :|..| ..:.
  Fly    75 I----ENEVFEKHSFEEKLQRLYKICSTMERPSLLRYFELVKPGEDL-NWPFLTPRGGKW-PKEK 133

  Fly   209 WTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSREY--LVKGFNETL--VT 269
            :.|.|.:.:.|..||: |.:...||..| .||     |..|..:...::|  |.: |.|:|  :.
  Fly   134 FQWMEALARLRRYGFN-DIMFGMSIRQD-PNS-----DSGQPIVVFEKKYDSLFR-FIESLQNIG 190

  Fly   270 AYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPY 334
            ...|...:||.|..|.:::.|::    ::||....:.:..........|:|.:.....|:..:
  Fly   191 LPPKLAKEIAPLDNAIQEMYKSD----MKFEHYARDAAPVKRISLGQLEIYGVSLTKYLEIVF-- 249

  Fly   335 VQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRI----------H 389
                         |...:.|.::::....:...|..|:...|.:|:|||:..|.          |
  Fly   250 -------------GRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKH 301

  Fly   390 G------------FSVGFLSEE---FRKRQLQYATALSG-----RQEQEARWKECVDIATSSMDE 434
            |            |:...|.||   .||:...|......     ||:...|.:..|.....:...
  Fly   302 GDSCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEIS 366

  Fly   435 VCEDDFDSLGISVGSLYVGKHFHK---DSKANALEMVN--EIRNVFNDILD-----EVNWMDAKT 489
            :.:...:.|.:|:|:| .||..|:   ......||..:  |:......:|:     |::.:|...
  Fly   367 LLQKKLNGLSLSIGNL-PGKAGHRRFVTRYYKELEFADDEELATAHLKVLEHRTRAELSLLDQPN 430

  Fly   490 KKEAKLKLHSMATHIGYP---------DEMLDNEKLAAY--YAKLDIDPDKYFESF----LGMNI 539
            .|:.:..|||      ||         .|...|....||  .|....|||.: :.|    ||:.
  Fly   431 FKDRRYMLHS------YPISNFFFETAYEENGNTIYVAYDFLADASFDPDSH-DIFKVTPLGIR- 487

  Fly   540 FGTDY--SFNKLRLPVNKTDW--------VRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQR 594
            ||.:.  ||:......:|.:.        :..|....|:|:  :.:|.:             :||
  Fly   488 FGLEMLKSFDLFNCKHHKVNMLQLFDDNQITTAGDECVSAW--TQDNLL-------------SQR 537

  Fly   595 PKYMNFGAIGYVIGHEITHGFDDQGRQF 622
            .:|:       |:.|.:...:..:|.:|
  Fly   538 DQYL-------VVLHLVHEAYFAEGSKF 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	126/592 (21%)
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	94/436 (22%)