DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and Kel

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	184/742 - (24%)
Similarity:	325/742 - (43%)	Gaps:	137/742 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDI 148
            |.:..|:...:..|........||.:|:.|||    |:.|     .:.::|..::::.:.:|..:
  Rat    58 CESPVCMELVNHYLASGNRSAAPCTDFFSFAC----EKAN-----GTSNSFQALAEENKSRLWKL 113

  Fly   149 ITAERPET------EPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADD 207
            :  |.|.:      |.|.|:    .|.:||:...||..|..|:.::.:.|||        ||...
  Rat   114 L--EAPGSWHLESGEEKAFQ----FYNSCMDTDAIEASGTGPLVQIIKELGG--------WNISG 164

  Fly   208 SWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNST-------------------KRLIDLDQS--S 251
            :||:                 .||:..:.|..|.                   ..:|.:||.  .
  Rat   165 NWTF-----------------FDFNQNLRLLMSQYGHFPFFRAYLHPHPAPPHTPIIQIDQPEFD 212

  Fly   252 LALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNS 316
            :.|.::...|.:.: ::..|..|:..:..|.|:|...|:.....|:.|...|.....|.::::..
  Rat   213 ILLQQDQEQKVYAQ-ILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQ 276

  Fly   317 SELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAK---TPKR 378
            .:|:::.|...||...|.:.|:..:.|:... ::::..:.:.:....:..::.:|:.:   ....
  Rat   277 DKLFHVVTIDALQEMAPAIDWLSCLQAIFTP-MSLSPSQTLQVHDLDYLRNMSQLVEEGLLNHSE 340

  Fly   379 VIANYMFWRIHGFSVGFLS-------EEFRKRQLQYATALSGRQEQEA--RWKECVDIATSSMDE 434
            :|.:||...:    |..||       :|.|:...|....|..|....|  ||.:||: .|.|..|
  Rat   341 IIQSYMILGL----VDTLSPALATKFQEARRELTQKLRKLKERPPLPAYPRWMKCVE-QTGSFFE 400

  Fly   435 VCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHS 499
            .          ::.:|:|.:.|....::.|:|:..||::.....|.:::|:..:|:|||..||..
  Rat   401 P----------TLAALFVHEAFGPSIRSAAMELFAEIKDAVIVRLKKLSWISEETRKEALNKLTQ 455

  Fly   500 MATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLG--MNIFGTDYSFNKLR-----LPVNKTD 557
            :...:|.|...|..|.....|:.:.:.| .:.:|||.  .::.|     .|:|     .|.::
  Rat   456 LQVEMGAPKRALKTEMAKQEYSDIQLGP-SFLQSFLSCVRSLQG-----RKVRSFLQPFPYHR-- 512

  Fly   558 WVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQF 622
            |.:  .|..|:|:||..::.:.||||:||..||:...|:.:||||:|.::.|::.|.|    .||
  Rat   513 WQK--SPWSVSAYYSVPDHVVVFPAGLLQPPFFHPGYPRAVNFGAVGSIMAHKLLHIF----FQF 571

  Fly   623 DVKGNLRDWWHP--DT---QKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKES 682
            .:.|..     |  ||   |:|.|    |:..:|..:...:.. :.||.:|..||.||.|||..:
  Rat   572 LLPGGC-----PACDTRALQEALL----CLEHRYAAFPLPSMS-SFNGSHTLLENAADIGGVAIA 626

  Fly   683 YIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSL 747
            :.|||:...:...|..||..:.:|.|:|:.:..|..|     ..|..:.....|||...||.|.|
  Rat   627 FQAYRKRITERTGELTLPNQELSPYQLFFRSYAQVMC-----RELISQDPQDTHSPPRLRVHGPL 686

  Fly   748 SNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ||..||||.|.||.||.:||..:|::|
  Rat   687 SNSPDFAKHFLCPSGSLLNPSTRCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	179/718 (25%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	180/723 (25%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	179/718 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920