DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and Mme

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	260/717 - (36%)
Similarity:	403/717 - (56%)	Gaps:	40/717 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQE 143
            |.| :|.:.:||.:|:.:::.|....|||.:|:::|||.:|:...||:.....|.|.::.|:|:.
  Rat    53 DDG-ICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEV 116

  Fly   144 QLKDIITAERPETEP-KHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNA-- 205
            .|||::  :.|:||. ...:....||::|:|::.|::.|.:|:..:...:.||| :...:|..
  Rat   117 ILKDVL--QEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWP-VASQNWEQTY 178

  Fly   206 DDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYL-VKGFNETLV 268
            ..|||.::.:.:..:. :....:|:|.:|.|.:|||:.:|..||..|.| ||:|. ..|..:...
  Rat   179 GTSWTAEKSIAQLNSK-YGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEAC 242

  Fly   269 TAYYKYMVDIAVLFGANRDLAKTELLLSL------EFEMALANISWPNEKRRNSSELYNLRTPAQ 327
            |||..:|:.:|.|....:.|...|..|||      |.|..:||.:...|.|.:...|||..|.|:
  Rat   243 TAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAK 307

  Fly   328 LQAAY-------PYVQWVDYMNALLPE-GLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYM 384
            ||..:       |: .|.::.|.::.. .:|:..:|.:.:..|.:...|..:|.|...|.:.|.|
  Rat   308 LQNNFSLEINGKPF-SWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLM 371

  Fly   385 FWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGS 449
            .||.....|..||..:::.:..:..||.|...:.|.|:.|.:....:|:.           :||.
  Rat   372 SWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMEN-----------AVGR 425

  Fly   450 LYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNE 514
            |||...|..:||....:::.:||.||...||::.||||:|||:|:.|..::...|||||:::.||
  Rat   426 LYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNE 490

  Fly   515 -KLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSI 578
             ||...|.:|:...::|||:.:....|.......|||..|:|.:|:..|  |:|||||||..|.|
  Rat   491 NKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGA--AVVNAFYSSGRNQI 553

  Fly   579 QFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAK 643
            .|||||||..||:|::...:|:|.||.||||||||||||.||.|:..|:|.|||...:...:..:
  Rat   554 VFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQ 618

  Fly   644 AKCIIEQYGNYT-ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPE 707
            ::|::.||||:| :.|.|.:||||||.|||||||||:.::|.||:.:.:|:|.|..|||||...:
  Rat   619 SQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHK 683

  Fly   708 QMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCE 772
            |:|::...|.||..||.|.....|.|.||||..||::|:|.|..:||..|||.:.|.|||.:||.
  Rat   684 QLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCR 748

  Fly   773 VW 774
            ||
  Rat   749 VW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	250/688 (36%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	249/686 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930