DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Kel

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	829	Identity:	201/829 - (24%)
Similarity:	339/829 - (40%)	Gaps:	193/829 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNWWRRRNKLEKSLLVSLGIMFVVLATGFG-LWIGKVLRTSPPSNPQATALHGDSTTINQVPTGT 71
            |..|.|  :|.::..|.|.::...|..|.. ||. .:.|...|.
Mouse    16 PTEWSR--QLTRARWVLLAVLLCGLLLGSSMLWF-YIFRNCGPC--------------------- 56

  Fly    72 ASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSV 136
                       .|.|..|:......|......|.||.:|:.|||    |:.|...|     :|..
Mouse    57 -----------PCETPVCMELLDHYLASGNRSVAPCTDFFSFAC----EKANGTSD-----SFQA 101

  Fly   137 ISDKLQEQLKDIITAERPET------EPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGW 195
            ::::.:.:|..::  |.|.:      |.|.|:    .|.:||:...||..|..|:.::.|.|||
Mouse   102 LTEENKSRLWRLL--EAPGSWHLGSGEEKAFQ----FYNSCMDTDAIEASGSGPLIQIIEELGG- 159

  Fly   196 PLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRL---------------- 244
                   ||...:||             |:|:           |...||
Mouse   160 -------WNITGNWT-------------SLDF-----------NQNLRLLMSQYGHFPFFRAYLR 193

  Fly   245 ------------IDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSL 297
                        ||..:..:.|.:|...|.:.: ::..|..|:..:..|.|:|...|:.....|:
Mouse   194 PHPAPPHTPIIQIDQPEFDILLQQEQEQKVYAQ-ILREYVTYLNRLGTLLGSNPQEAQQHASWSI 257

  Fly   298 EFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSV 361
            .|...|.....|.::::...:|:::.|..:||...|.:.|:..:.|:. |..||.::..:::  .
Mouse   258 VFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVH--D 320

  Fly   362 PSFFEDLGKLLAK---TPKRVIANYMFWRIHGFSVGFLS-------EEFRKRQLQYATALSGRQE 416
            ..:..::.:|:.:   ..:..|.:||...:    |..||       :|.|:..:|....|..|..
Mouse   321 LDYLRNMSQLVEEGLLNHRESIQSYMILGL----VDTLSPALDTKFQEARRELIQELRKLKERPP 381

  Fly   417 QEA--RWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDIL 479
            ..|  ||.:||: .|.:..|.          ::.:|:|.:.|....::.|:|:..||::.....|
Mouse   382 LPAYPRWMKCVE-QTGAFFEP----------TLAALFVREAFGPSIQSAAMELFAEIKDAVIIRL 435

  Fly   480 DEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFL--------- 535
            .:::|:..:|:|||..||..:...:|.|...:..:.....|..:.:.| .:.:|||
Mouse   436 KKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQLGP-SFLQSFLSCVRSLRAR 499

  Fly   536 GMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNF 600
            .:..|...:.:::.:    |:.|.       |||:||..::.:.||||:||..||:...|:.:||
Mouse   500 NVQSFLQPFPYHRWQ----KSPWE-------VNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNF 553

  Fly   601 GAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHP--DT---QKAYLAKAKCIIEQYGNYTERATG 660
            ||.|.::.||:.|.|    .|..:.|..     |  ||   |:|.|    |:...|..:...:..
Mouse   554 GAAGSIMAHELLHIF----YQLLLPGGC-----PACDTHVLQEALL----CLERHYAAFPLPSIS 605

  Fly   661 LNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKE 725
             :.||.:|..||.||.|||..::.||.:...:|..|..||.||.:|.|:|:.:..|..|     .
Mouse   606 -SFNGSHTLLENAADIGGVAIAFQAYSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMC-----R 664

  Fly   726 SLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .|..:.....|||...||.|.|||..||||.||||.|:.:||..:|::|
Mouse   665 GLSSQDPQDPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	183/728 (25%)
Kel	NP_115929.3	M13	78..711	CDD:341056	183/728 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920