DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Ece1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001356106.1	Gene:	Ece1 / 230857	MGIID:	1101357	Length:	769	Species:	Mus musculus

Alignment Length:	779	Identity:	278/779 - (35%)
Similarity:	414/779 - (53%)	Gaps:	82/779 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRRRNKLEKSLLVSLGIMFVVLATGF-----GLWIGKVLRTSPPSNPQATALHGDSTTINQVPTG 70
            |..|..:||.|:|    :..:||.|.     .|.|....||.|
Mouse    58 WAARTSVEKRLVV----LVTLLAAGLVACLAALGIQYQTRTPP---------------------- 96

  Fly    71 TASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFS 135
                        ||||:.|:...|::|..|.|.|:||.:|:.:|||.:::...:||......|||
Mouse    97 ------------VCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFS 149

  Fly   136 VISDKLQEQLKDII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPL 197
            .:.:..|..:|.::   ||...|.|    |...:.|:||||:|.||.|..:|:..:.|:||||.:
Mouse   150 NLWEHNQAVIKHLLENATASVSEAE----RKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNI 210

  Fly   198 IKGDSWNADDSW--TWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-Y 258
            .  ..| |.|::  |.|.....:||:.|...|     :..|.:||...:|.:|||.|.| ||: |
Mouse   211 T--GPW-AKDNFQDTLQVVTAHYRTSPFFSVY-----VSADSKNSNSNVIQVDQSGLGLPSRDYY 267

  Fly   259 LVKGFNETLVTAYYKYMVDIA-VLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNL 322
            |.|..||.::|.|..|||.:. :|.|.:.|..:.::...|:||.|||||:.|.||||:...:|:.
Mouse   268 LNKTENEKVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHK 332

  Fly   323 RTPAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFW 386
            .|.|:||...|.:.|:.::|.:. |..:|  |.|.|.:....:...:..|:..|.|.::.|||.|
Mouse   333 VTAAELQTLAPAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMW 395

  Fly   387 RIHGFSVGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSL 450
            .:...:..||.:.|:....::...:.|.::. ..|||.||           .|..::||.::|.:
Mouse   396 NLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCV-----------SDTENNLGFALGPM 449

  Fly   451 YVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEK 515
            :|...|.:|||..|.|::.||:..|.:.|..:.|||.:|::.||.|..::...||||:.::|.::
Mouse   450 FVKATFAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKE 514

  Fly   516 LAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQF 580
            |...:......||.|||:.:....|....:.::||...|:..|  ...|.:|||:||..:|.|.|
Mouse   515 LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQW--SMTPPMVNAYYSPTKNEIVF 577

  Fly   581 PAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAK 645
            ||||||..|:....|..:|||.||.|:|||:||.||||||::|..||||.||...:.:|:..:.:
Mouse   578 PAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTE 642

  Fly   646 CIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMF 710
            |:::||.||:  ..|..:||.:|.|||||||||:|.:|.||:.|.:|:|.|..||.|..|..|:|
Mouse   643 CMVQQYSNYS--VNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLF 705

  Fly   711 WVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ::...|.||:....||....:.|..||||.|||:|||||.|:|::.|.||.||||||..|||||
Mouse   706 FLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	251/677 (37%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	251/677 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.780