Protein Alignment Nep2 and nep-24

DIOPT Version :9

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_503005.3
• Gene: nep-24 / 190993
• WormBaseID: WBGene00013786
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 624
• Identity: 137/624 - (21%)
• Similarity: 228/624 - (36%)
• Gaps: 145/624 - (23%)

  Fly    82 DVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLK 146
            :||.|..||..|..:.....|.|:|||||::||||.  |.|:..:|..:..| ..|::.::..||
 Worm    36 NVCNTPACITLAHMLHNYHDPSVDPCDNFHQFACGR--EHEHETEDIYTKKT-KTINNIMKRFLK 97

  Fly   147 DIITAERPETEPKHFRLPNLLYKAC----MNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADD 207
            ...|: |.::|    .....|||||    .|.|.......:.|.:..:.:|.||::       ||
 Worm    98 KNETS-RSKSE----NAMRTLYKACKTLEKNSTASRNKALQDIFQDIQSIGAWPVV-------DD 150

  Fly   208 SWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL---SREYLVKGFNETLVT 269
            .|    ...||                 ||.:....|:.|.:.:..|   :|...|:.|
 Worm   151 KW----DESKF-----------------DLNDFLVNLVRLGRKNFGLFQMARYVNVRNF------ 188

  Fly   270 AYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKR--RNSSELYNLRTPAQ----- 327
                 .:.....:..|.||.||   :|   |:..||....|.|:  .:.:|..||.....
 Worm   189 -----AIGPEAAWRHNVDLGKT---IS---EILKANSVQTNNKKLLDDLAEYVNLEKALSQHKFN 242

  Fly   328 -LQAAYPYVQWVDYMNA-----------------LLPEGLNVAEDEMINLSVPSFF---EDLGKL 371
             :|..|.:.:..|::::                 |.||...:.  .:.|.|:  ||   .:|..:
 Worm   243 TVQPGYIFSERSDFVSSVNFSRLVLEMMSPDKRTLFPEVYQIM--YLTNTSL--FFGKNNNLETI 303

  Fly   372 LAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVC 436
            :..|.||.:|||:.::....|:                               .|:...|....|
 Worm   304 IRNTSKRALANYLIFKFIDTSI-------------------------------ADLTYGSPSAFC 337

  Fly   437 EDD-FDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSM 500
            |.. .:.|..:....:......|:::....::....:.....|:...:||..|:||.|..::.||
 Worm   338 EQKVINFLPRAALRAFYRNFISKENRKKITKLTEATQVQLLKIIGATDWMSIKSKKIAMDRVSSM 402

  Fly   501 ATHIGYPDEMLDNEKLAAYYAKLDI-DPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARP 564
            ...|||||......||...:..|:: ..|.|:.....:|.|          :...:.|:.....|
 Worm   403 NMVIGYPDYFDPPGKLDGLFEHLNLSSSDTYYTVVRKINRF----------MREQEMDYYTGEVP 457

  Fly   565 -------AIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQF 622
                   .:.||.|::.:|::...|......||::..|.|.|.......:.||:.|.|..  ...
 Worm   458 YYPLFPGLMTNAMYNANDNNLMIFAPFFDDPFFDSSFPDYANIAFTSNTLAHEMGHTFSP--HLM 520

  Fly   623 DV-KGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATG 660
            |: .|....|..|...:.|..:.||:.:||..|.:...|
 Worm   521 DIMTGTTEVWLTPKETEEYEKRVKCLEDQYTEYDDPEYG 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	130/602 (22%)
nep-24	NP_503005.3	GluZincin	58..561	CDD:301352	130/602 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920