DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and ECE1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	777	Identity:	280/777 - (36%)
Similarity:	420/777 - (54%)	Gaps:	78/777 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRRRNKLEKSLLVSLGIMFVVLATGFGLW---IGKVLRTSPPSNPQATALHGDSTTINQVPTGTA 72
            |..|.::||.|:|    :.|:||.|....   :|...:|..||
Human    67 WAARTQVEKRLVV----LVVLLAAGLVACLAALGIQYQTRSPS---------------------- 105

  Fly    73 SKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVI 137
                      |||::.|:...|::|..|.|.|:||.:|:.:|||.:::...:||......|||.:
Human   106 ----------VCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNL 160

  Fly   138 SDKLQEQLKDII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIK 199
            .:..|..:|.::   ||...|.|    |...:.|:||||:|.||.|..:|:..:.||||||.:.
Human   161 WEHNQAIIKHLLENSTASVSEAE----RKAQVYYRACMNETRIEELRAKPLMELIERLGGWNIT- 220

  Fly   200 GDSWNADDSW--TWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLV 260
             ..| |.|::  |.|.....:||:.|...|     :..|.:||...:|.:|||.|.| ||: ||.
Human   221 -GPW-AKDNFQDTLQVVTAHYRTSPFFSVY-----VSADSKNSNSNVIQVDQSGLGLPSRDYYLN 278

  Fly   261 KGFNETLVTAYYKYMVDIA-VLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRT 324
            |..||.::|.|..|||.:. :|.|.:.:..:.::...|:||.|||||:.|.||||:...:|:..|
Human   279 KTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 343

  Fly   325 PAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRI 388
            .|:||...|.:.|:.::|.:. |..:|  |.|.|.:....:.|.:..|:..|.:.::.|||.|.:
Human   344 AAELQTLAPAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNL 406

  Fly   389 HGFSVGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYV 452
            ...:..||.:.|:....::...:.|.::. ..|||.||           .|..::||.::|.::|
Human   407 VRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV-----------SDTENNLGFALGPMFV 460

  Fly   453 GKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLA 517
            ...|.:|||:.|.|::.||:..|.:.|..:.|||.:|:|.||.|..::...||||:.::|.::|.
Human   461 KATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELD 525

  Fly   518 AYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPA 582
            ..:......||.|||:.:....|....:.::||...|:..|  ...|.:|||:||..:|.|.|||
Human   526 KVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQW--SMTPPMVNAYYSPTKNEIVFPA 588

  Fly   583 GILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCI 647
            ||||..|:....||.:|||.||.|:|||:||.||||||::|..||||.||...:.:|:..:.:|:
Human   589 GILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECM 653

  Fly   648 IEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWV 712
            :|||.||:  ..|..:||.:|.|||||||||:|.:|.||:.|.:|:|.|..||.|..|..|:|::
Human   654 VEQYSNYS--VNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFL 716

  Fly   713 AAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ...|.||:....||....:.|..||||.|||:|||||.|:|::.|.||.||||||..|||||
Human   717 GFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	254/677 (38%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	253/683 (37%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	254/677 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.780