Protein Alignment Nep2 and nep-18

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 782
• Identity: 166/782 - (21%)
• Similarity: 324/782 - (41%)
• Gaps: 168/782 - (21%)

  Fly    68 PTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDD----- 127
            |:| :|...:| |.:.|.::||:...:.:.......|:||::|:|..||.|  .|::.||
 Worm    13 PSG-SSNAPNG-SPETCWSKECVGVLAMIKNYQNASVDPCEDFFEHTCGRY--SEHVMDDNSWGY 73

  Fly   128 ----KVSISTFSV------ISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGP 182
                ::....|::      .:.|..|||:                   :..|:|:::..::....
 Worm    74 VQYKQLLYQVFAIARKTNKFNSKPNEQLR-------------------IFTKSCLDRKEMDEDTF 119

  Fly   183 EPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKF------RTAGFSMD--------------- 226
            :.:....|..||:|:| ..:|| ::.:...:.:.|:      |....|::
 Worm   120 QDLRNDIEERGGFPMI-DPNWN-EEKFDLSDMLAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLY 182

  Fly   227 ------YIIDFSIGVDLQNST-----KRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAV 280
                  ::.::::|:.:...:     :||:.|:...|           |||:....:..:|.:..
 Worm   183 VSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENREL-----------NETIYDKEFAELVQLEA 236

  Fly   281 LFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALL 345
            .|....|...    |:|:.:    |:|    |.||.::|..:         .|.:.|:..:.||.
 Worm   237 NFSTLADYRN----LALDND----NMS----KSRNLTDLVKM---------IPEIDWIKILKALA 280

  Fly   346 PEGLNVAEDEMI--NLSVPS----FF---EDLGKLLAKTPKRVIANYMFWR-IHGFSVGFLSEEF 400
            ..|.:..::|.:  .::|..    ||   .:|.::..:|||..:|||:..| :...::.|..::
 Worm   281 RHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYFYDKD- 344

  Fly   401 RKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCE-DDFDSLGISVGSLYVGKHFHKDSKANA 464
                          |.::.::...||..:....:|.. ....|:.:.:.|    ..|..::....
 Worm   345 --------------QPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIES----SQFKIENLKVI 391

  Fly   465 LEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLD-IDPD 528
            .||..:|:..:..|..|..:::.:.::....||:::....|..........|...|..|: :|.|
 Worm   392 EEMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTD 456

  Fly   529 KYFESFLGM-----------NIFGTDYSFNKLRLPVNKTDWVRHA--RPAIVNAFYSSLENSIQF 580
            ..::.::.|           .:..|...      |||...:..||  :| ..|.||.:|. .:.:
 Worm   457 SPWQVYMKMWRHWSEQLVEHIVHDTPLD------PVNLKMFGTHAAYQP-YPNHFYINLP-YLTY 513

  Fly   581 PAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKA---YLA 642
            |       :.:|..|...|:|.:||||||||.|.||...|:.|..|..:.:|..:|..:   |..
 Worm   514 P-------WMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYEL 571

  Fly   643 KAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPE 707
            :.||:.:||..|.|......:||.:.:.|...|:.|::.::..:.:  .|.....:||||:.:.|
 Worm   572 REKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEK--VKKEDRFRLPGLEMSEE 634

  Fly   708 QMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCE 772
            |:|:.......|..|....|...:....|..:.:||.|.:.|:.:||:.|:||:.|||||..||:
 Worm   635 QLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCK 699

  Fly   773 VW 774
            ::
 Worm   700 LY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	157/742 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	157/742 (21%)