DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-18

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	166/782 - (21%)
Similarity:	324/782 - (41%)	Gaps:	168/782 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDD----- 127
            |:| :|...:| |.:.|.::||:...:.:.......|:||::|:|..||.|  .|::.||
Worm    13 PSG-SSNAPNG-SPETCWSKECVGVLAMIKNYQNASVDPCEDFFEHTCGRY--SEHVMDDNSWGY 73

  Fly   128 ----KVSISTFSV------ISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGP 182
                ::....|::      .:.|..|||:                   :..|:|:::..::....
Worm    74 VQYKQLLYQVFAIARKTNKFNSKPNEQLR-------------------IFTKSCLDRKEMDEDTF 119

  Fly   183 EPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKF------RTAGFSMD--------------- 226
            :.:....|..||:|:| ..:|| ::.:...:.:.|:      |....|::
Worm   120 QDLRNDIEERGGFPMI-DPNWN-EEKFDLSDMLAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLY 182

  Fly   227 ------YIIDFSIGVDLQNST-----KRLIDLDQSSLALSREYLVKGFNETLVTAYYKYMVDIAV 280
                  ::.::::|:.:...:     :||:.|:...|           |||:....:..:|.:..
Worm   183 VSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENREL-----------NETIYDKEFAELVQLEA 236

  Fly   281 LFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALL 345
            .|....|...    |:|:.:    |:|    |.||.::|..:         .|.:.|:..:.||.
Worm   237 NFSTLADYRN----LALDND----NMS----KSRNLTDLVKM---------IPEIDWIKILKALA 280

  Fly   346 PEGLNVAEDEMI--NLSVPS----FF---EDLGKLLAKTPKRVIANYMFWR-IHGFSVGFLSEEF 400
            ..|.:..::|.:  .::|..    ||   .:|.::..:|||..:|||:..| :...::.|..::
Worm   281 RHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYFYDKD- 344

  Fly   401 RKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCE-DDFDSLGISVGSLYVGKHFHKDSKANA 464
                          |.::.::...||..:....:|.. ....|:.:.:.|    ..|..::....
Worm   345 --------------QPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIES----SQFKIENLKVI 391

  Fly   465 LEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLD-IDPD 528
            .||..:|:..:..|..|..:::.:.::....||:::....|..........|...|..|: :|.|
Worm   392 EEMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTD 456

  Fly   529 KYFESFLGM-----------NIFGTDYSFNKLRLPVNKTDWVRHA--RPAIVNAFYSSLENSIQF 580
            ..::.::.|           .:..|...      |||...:..||  :| ..|.||.:|. .:.:
Worm   457 SPWQVYMKMWRHWSEQLVEHIVHDTPLD------PVNLKMFGTHAAYQP-YPNHFYINLP-YLTY 513

  Fly   581 PAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKA---YLA 642
            |       :.:|..|...|:|.:||||||||.|.||...|:.|..|..:.:|..:|..:   |..
Worm   514 P-------WMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYEL 571

  Fly   643 KAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPE 707
            :.||:.:||..|.|......:||.:.:.|...|:.|::.::..:.:  .|.....:||||:.:.|
Worm   572 REKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEK--VKKEDRFRLPGLEMSEE 634

  Fly   708 QMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCE 772
            |:|:.......|..|....|...:....|..:.:||.|.:.|:.:||:.|:||:.|||||..||:
Worm   635 QLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCK 699

  Fly   773 VW 774
            ::
Worm   700 LY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	157/742 (21%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	152/740 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	157/742 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920