Protein Alignment Nep2 and Phex

DIOPT Version :9

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 726
• Identity: 241/726 - (33%)
• Similarity: 384/726 - (52%)
• Gaps: 61/726 - (8%)

  Fly    82 DVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLK 146
            :.||..|||..|:.::.|:...|:||:||:.|||..::....||:|..|...:..:...:..:||
Mouse    52 EYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLK 116

  Fly   147 DII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLG-GWPLIKGDSWNADD 207
            .::   .:.|.:||.  .:...:||.:|||:..||....:|:..:..... .||:::.   |...
Mouse   117 ALLEKSVSRRRDTEA--VQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEA---NIGP 176

  Fly   208 SWTWQEQ-------VKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQS--SLALSREYL---- 259
            ...|.|:       :..|| ..:|....|...:..|.:.|.:.::.|||:  |||:..::|
Mouse   177 EGVWSERKFSLLQTLATFR-GQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTT 240

  Fly   260 -VKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLR 323
             .|.:.:.|    ||:|||.|||.|||...|:.::...|..|:.:|.|..|:| .|.|..:||..
Mouse   241 EAKSYRDAL----YKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHE-NRTSEAMYNKM 300

  Fly   324 TPAQLQAAYPYVQWVDYM-----NALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANY 383
            ..::|.|..|...|:.|:     ..|.|...::...|.:.:.||.:|:||.::|....|:.||||
Mouse   301 NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANY 365

  Fly   384 MFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVG 448
            :.||:....:..||..|:.|.|:::..:.|......:|.:||:...|::..|           ||
Mouse   366 LVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYV-----------VG 419

  Fly   449 SLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVN-WMDAKTKKEAKLKLHSMATHIGYPDEMLD 512
            .::|..||.:|.|....|::..:|..|.|:|::.| ||||.||::|:.|..::...:|||:.:::
Mouse   420 KMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMN 484

  Fly   513 ----NEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSS 573
                ||.|.|    :......||.:.|....:.....|..||..|.||:|  ...|..||||||:
Mouse   485 DTYVNEDLKA----IKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEW--FTNPTTVNAFYSA 543

  Fly   574 LENSIQFPAGILQGHFF-NAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQ 637
            ..|.|:||||.||..|| ..:.|:.:::||||.::|||.|||||:.||::|..|||..||..:::
Mouse   544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESE 608

  Fly   638 KAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWA--EKHG-PEAKL 699
            :.:..|.||:|.||.||..:..|||:.|..|.|||||||||::|::.|||:|.  .:.| .|..|
Mouse   609 EKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLL 673

  Fly   700 PGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSP 764
            ||:.:|..|:|:::.....|..||.|:.:.::..|.|||.:|||.|::||.::|.|.|:||..|.
Mouse   674 PGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNST 738

  Fly   765 MN-PVQKCEVW 774
            || ....|.:|
Mouse   739 MNRGADSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	232/700 (33%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	232/701 (33%)
		M13	74..747	CDD:189000	232/700 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930