Protein Alignment Nep2 and nep-8

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 162/735 - (22%)
• Similarity: 287/735 - (39%)
• Gaps: 168/735 - (22%)

  Fly    73 SKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVI 137
            |.|...||.::|.:.|||..:..:|....|.|:||.:|::.:||.:.|:      .||.|.....
 Worm    45 SIGNDVDSKNLCDSPECITLSHELLNYQDPSVDPCVDFFQHSCGRFHEQ------SVSESRLQKK 103

  Fly   138 SDKLQEQLKDIITAERPETEPKHFRLPNLLYKAC--MNKTLIETLGPEPITRVA--------ERL 192
            ...|::|:::.:...:..|. |...|..|::..|  ..||..:..   .|:|.|        :::
 Worm   104 KHILRKQIREFLHKIQNSTS-KSENLMKLVFDKCEASKKTSNDNY---KISRDAIHDVFNDIKKI 164

  Fly   193 GGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSR- 256
            |.|||:       |.:|    ...||                 ||......|:.|..::|.|.:
 Worm   165 GAWPLL-------DKNW----DGSKF-----------------DLNEMLSNLVKLGATNLGLFQL 201

  Fly   257 --EYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSS-- 317
              ..|.:|          |: |.||...|:   :.....::|:..|:..||...|:.:..:..
 Worm   202 DFRILTEG----------KF-VRIAPTLGS---IVHNSTMISMISEILEANGVQPDSEEISKEFE 252

  Fly   318 -------ELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLN-------VAEDEMINLSVPSFF--- 365
                   :|...::..:|..:.|.|:.::: ::|:.|.::       ..:..::....|.||
 Worm   253 EYSSLQMKLAKYQSSGKLSISLPGVRSINF-SSLITEMIHPSRVSKIFGKIRVVTSEHPLFFKSN 316

  Fly   366 --EDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIA 428
              |.|..::..|..:.:||::.              |...|..|......|:..
 Worm   317 ETESLDTIIESTSNKTLANFLI--------------FNYIQSSYNIMKGARRGN----------- 356

  Fly   429 TSSMDEVCEDD----FDSLGISV--------GSLYVGKHFHKDSKANALEMVNEIRNVFNDILDE 481
                   ||||    |....:.|        |:....|...::.|.|.|||:.:..|:
 Worm   357 -------CEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTENL------- 407

  Fly   482 VNWMDAKTKKEAKL-KLHSMATHIGYPDEM-----LDNEKLAAYYAKLDID-PDKYFESFLGMNI 539
                 |...||:.| |:.::...|||||..     ||.|     :...|:| .|.|:..|..:|.
 Worm   408 -----APPVKESMLKKVEAIKVTIGYPDHFDPPGTLDKE-----FENFDLDSTDSYYRIFQKLNR 462

  Fly   540 FGTDYSFNKL--RLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGA 602
            ..::.....:  ..|::....|..     |||.|...:|::...|..|...||:...|.|:|...
 Worm   463 LRSEQQMEFIAGETPISPIKEVLK-----VNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFF 522

  Fly   603 IGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGIN 667
            .|::|.|||.|..|..|..:|..|...|....:....|..:.:|:::||.||.:...|..:||.:
 Worm   523 SGFLIAHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTH 587

  Fly   668 TQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGL-DYTPEQMFWVAAGQTWCAKYRKESLKMRI 731
            :..|.|||..|.:.::.||::.  .......|.|| |...:|:::......:|.:  ::::.:..
 Worm   588 SINEIIADWVGHEVTWRAYKKM--DTSKMLSLIGLKDINMDQLYFRVQSLLFCRE--RDTISLEE 648

  Fly   732 T-TGVHSPSEFRVLGSLSNM 750
            | ..|:....|||.|:.:.:
 Worm   649 TLKDVYPTDNFRVNGAYARV 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	152/704 (22%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	151/698 (22%)