DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-6

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_494537.1	Gene:	nep-6 / 184628	WormBaseID:	WBGene00017550	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	816	Identity:	209/816 - (25%)
Similarity:	316/816 - (38%)	Gaps:	228/816 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEP 106
            |..|..|.:||        .|.....|...|||.:     :||.|..|:..|..:|....|.|:|
Worm    56 KKSRPEPVTNP--------VTMTRPEPVTQASKPR-----NVCETPGCVTLADQLLNFQDPSVDP 107

  Fly   107 CDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAE-------RPET-EPKHFRL 163
            |.:||:.|||.|.|.|             |.:.:||:  ||||...       :.|| |.|...:
Worm   108 CQDFYKAACGKYSEHE-------------VANRRLQK--KDIIIQRMIKNFLLKNETSESKSENV 157

  Fly   164 PNLLYKACMN-----------KTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQE---- 213
            ...:|:.|..           ||....|..:     .:::|.||.       ||.:|...:
Worm   158 MRQVYRTCEGLKNEEIFNANMKTAFRELFKD-----IQKIGSWPA-------ADKNWDETKLNLN 210

  Fly   214 ----QVKKFRTAGFSMDYI----IDF-SIGVDLQNSTKRLIDLDQSSLALSREYLVKGFNETLVT 269
                .:.|..::.|.:..|    :.| .:..|:..|.|                         |:
Worm   211 EMLLNIVKLGSSNFGLFQIRPTEVPFLEVAPDMARSPK-------------------------VS 250

  Fly   270 AYYKYMV-DIAVLFGANRD----LAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQ 329
            |.::.:: ||....|...|    ....|..::||..::.....:..||.:.|          :||
Worm   251 ANFQQIIFDILEKNGLQPDENVIADDVEDYITLEETLSQYAYDYNAEKVQFS----------KLQ 305

  Fly   330 AAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPS---------FFED---LGKLLAKTPKRVIAN 382
            |..|.::    :..::.|.:|....:::...|..         ||::   |.|||..||||.:||
Worm   306 AQVPSLK----LEKIIEEMMNPNRKKLLVTKVKPRMVAHKHSLFFDEKMNLEKLLKSTPKRTLAN 366

  Fly   383 YMFW-----RIHGFSVGFLSEEFRKRQ-----LQYATALSGRQEQEARWKECVDIATSSMDEVCE 437
            |:.:     .::|.||.  ....:||.     ::|....|.|
Worm   367 YLIFYYMDHAMNGLSVH--DNVIKKRNCEKLVIEYLPKASLR----------------------- 406

  Fly   438 DDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMAT 502
                        ::|..||.|.:.....||..|.:..|.::|.|..|:.|.:||.|.|||..|..
Worm   407 ------------VFVRNHFEKGNLKIVDEMAEETKKSFIEMLQESTWLGADSKKNAILKLEKMGK 459

  Fly   503 HIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLR----------------- 550
            .||||.|.   ||..|.        ||.||:   :.:...|..:..|:
Worm   460 MIGYPKEF---EKKGAL--------DKMFET---LKLLPKDTLYGILKKIGRFHMEQGIEFVALE 510

  Fly   551 ------LPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGH 609
                  |||..|           ||||:. .|.:.|..|.:....|:|..|||:|....|.::.|
Worm   511 TPMDPVLPVLMT-----------NAFYTD-RNHLSFLVGYMDDPLFDATYPKYVNIALTGNILAH 563

  Fly   610 EITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIA 674
            |.:||||..|.:.|..|.:|.|..|:..|.|..|.:|:::||..|.:...|.||||..|..|.:|
Worm   564 ETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNGTTTLNEMVA 628

  Fly   675 DNGGVKESYIAYRRWAEKHGPEAKLPGLD-YTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSP 738
            |..||..::..:.:.  ....|.|:.|.: ...:::::.||...:|:.....||...:|. ||..
Worm   629 DMIGVTVAWKVFEKL--DSSKEQKVIGFENENIDKLYFRAAALDFCSLPPTTSLVEELTR-VHPT 690

  Fly   739 SEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ..|||.|..|||..||..|:|||||||||..:|.::
Worm   691 GNFRVNGIFSNMPQFATAFNCPEGSPMNPKTRCSIF 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	191/750 (25%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	191/750 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920