DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-22

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	855	Identity:	218/855 - (25%)
Similarity:	359/855 - (41%)	Gaps:	176/855 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IMFVVLATGFGLW--------IGKV--LRTSPPSNP-----QATALHGDSTTINQVPTGTASKGK 76
            |..||:|.|..:.        :|.|  |.|:..:||     .|..::....|:|..|:.|
Worm    10 IAAVVIAVGIAIGSLVLNIIILGNVNTLTTTVNNNPVYHYTPAPQVNSTPGTVNTSPSYT----- 69

  Fly    77 SGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPD---------DKVSIS 132
                          ..|:.:|..:...|:||.:||.|.|..:|:..::..         |:..:.
Worm    70 --------------QAANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVD 120

  Fly   133 TFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYKACMN-------KTLIETLGPEPITRVAE 190
            .:|.|...|.:  .|:.:....:||    |:....::.|.|       ||.:      ....:..
Worm   121 VYSEIVAALSK--IDVTSTTTSKTE----RITKAAFETCKNNLASPADKTAV------VYAEITS 173

  Fly   191 RLGGWPLIKGDSWNAD-DSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL 254
            ..||.|.. |:....: |.|....|:::....| ::.|.|..|   |.::.||..:......|:|
Worm   174 LFGGVPFF-GEPLKTNVDYWMVAGQIEQKHAVG-TLTYTIASS---DYKDHTKNALYTGPPGLSL 233

  Fly   255 SREYLVKGFNETLVTAYYKYMVDIAVLF--------GANRDLAKTELLLSLEFEMALANISWPNE 311
            :|::.||......|......:.|:...|        ||:..||..:.:::.|.::|:|  |||::
Worm   234 ARDFYVKPQYIAEVNQRVSDVNDLLTAFANAAKKNVGADALLAAAQEVVNFEVQIAMA--SWPDD 296

  Fly   312 KRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSV--PSFFEDLGKLL-A 373
            ..||..:.||....|....||..:.|..|:..|.....:.|:....|:.|  ||:|..|..:. .
Worm   297 LLRNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDG 361

  Fly   374 KTP-KRVIANYMFWRIHGFSVGFLSEEFRK-----RQLQYATALSGR-----QEQEARWKE---- 423
            ||. ..|:||||..::......|::....|     ..:.||.. :||     .::|.|..:
Worm   362 KTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALR-NGRGIKKIGKREYRMADLDGI 425

  Fly   424 ---CVDIATSSMDEVCEDDFDSLGISVGSLYV-GKHFHKDSKANALEMVNEIRNVFNDILDEVNW 484
               |:|:.|:.|.           ...|.:|| .|......:|:..:....|.|.|..::|.:||
Worm   426 SEGCMDLLTAYMP-----------YGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLNW 479

  Fly   485 MDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYS---- 545
            ||..:|..|..|..|:..:.|:|:.|..:                 |..|..::.:..||:
Worm   480 MDTFSKNRAHNKSDSLVKNFGWPEAMFGD-----------------FNDFTTVDAYNQDYASIID 527

  Fly   546 -------------------------FNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGIL 585
                                     |..:..|.::|::::  .||:|||:|....|||.||....
Worm   528 LYTKDKNDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQ--SPAMVNAWYQPERNSITFPYAAW 590

  Fly   586 QGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRD-------WWHPDTQKAYLAK 643
            ...::|...|:..||...|...|||:|||:||:|.||...|.|.|       |...::...::..
Worm   591 NPPYYNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDM 655

  Fly   644 AKCIIEQYGNY--TERATGLN-LNGINTQGENIADNGGVKESYIAYRRW---AEKHGPEAKLPGL 702
            |:|::.|:...  .|:...:: .||..||||||||.||.:.:|.:||::   ..|...|.:||||
Worm   656 AQCVVTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGL 720

  Fly   703 D-YTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPM- 765
            : |||.|:||:..|.:||.|....:|..::.|..|||::.|....:.::.:|.|||.|..||||
Worm   721 ENYTPNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMY 785

  Fly   766 -NPVQKCEVW 774
             .|..:|:||
Worm   786 PEPSGRCKVW 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	197/759 (26%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	199/768 (26%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	197/759 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920