DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-16

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001023203.2	Gene:	nep-16 / 177541	WormBaseID:	WBGene00018472	Length:	868	Species:	Caenorhabditis elegans

Alignment Length:	747	Identity:	142/747 - (19%)
Similarity:	280/747 - (37%)	Gaps:	164/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQ 144
            |.:||.|::||..|..:...:..|:|||:|||.::|..|..:   ..|| .:|..|.:.|:...:
Worm   230 STNVCNTRQCIDIAFRLSSCIDDEIEPCENFYRYSCQRYHSQ---TADK-QMSFLSQLKDESLRR 290

  Fly   145 LKDIITAER-PETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNAD-D 207
            :..::::|. ....||..||...||.||||..|..:..|..:..........||:: |..|.. |
Worm   291 MHSLLSSEEDSRLLPKSARLSRSLYSACMNAVLRSSNAPTDLLTFIRNFPCGPLLR-DCQNFHAD 354

  Fly   208 SWTWQEQVKKFRTAGFSMDY------IIDFSIGVDLQNSTK-------------------RLIDL 247
            |::|:      |.||. :|:      :|.:...|..|:.:|                   .||||
Worm   355 SYSWE------RHAGM-LDWYAGRYNLIVYDRDVHPQDRSKIILQIKPPDLTPIVGLIERDLIDL 412

  Fly   248 DQSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAK-----TELLLSLEFEMALANIS 307
            .:.|.......|.....:.|::|:.:     ..|....||:..     ..|::.|......:...
Worm   413 ARPSPTEFEPLLQLSLRQNLLSAFAR-----DSLLRDPRDVQSQLDEVARLMVDLYISARQSASL 472

  Fly   308 WPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLL 372
            .||.......|::.         |.|.:...::::|.|.......|.:|:::....:|..|..::
Worm   473 TPNTTYMTIGEMFQ---------ALPQLYLREFLDAQLSNTYRWTETDMLSIQDYDYFARLSDIM 528

  Fly   373 AKTPKRVIANYMF----WRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMD 433
            |:|.::.:|||:.    |.:..:|       :..|. ||.            |:||||
Worm   529 AQTSRQAVANYLLTVTVWNLKQYS-------YSPRD-QYG------------WRECVD------- 566

  Fly   434 EVCEDDFDSLGISVGSLYVGKHFHKDSKANALEM--VNE-IRNVFNDILDEVNWMDAKTKKEAKL 495
                        .:.|..:|:..:.|..:..:::  :.| ::|:..|.|.    :...|..:...
Worm   567 ------------QISSFEIGRKMYVDKASQTIDLPKIQEFLQNLKIDFLS----VHRSTPLQYLS 615

  Fly   496 KLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVR 560
            .::.:..::|:|..:.:.|.:....:::.::...||:|.:.:.....||:.:::...::..|...
Worm   616 NINRLGFYVGFPRRLQNEELIWKPVSQVSLNETDYFDSMIRVGKAERDYTMSQIGTYLDNDDTTT 680

  Fly   561 H--ARPAIVNAFYSSLENSIQFPAGILQGHFF--NAQRPKYMNFGAIGYVIGHEITHGFDDQGRQ 621
            .  :.|.::   |:|...:|..|...::...:  ..:.|.|..:.::|......|:..|
Worm   681 FPISDPTML---YNSNVGAIVIPLAFIEPPIYLPGDEVPMYGIYSSLGITTLQMISKVF------ 736

  Fly   622 FDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTE--RATGLNLNGINTQGENIADNGGVKESYI 684
                     |...|.    .::.:|:...:..:.:  |....|:.........:||  ..|.:..
Worm   737 ---------WQGLDK----TSQLECLDNVFRGFLDANRQRSPNIEPELLATIELAD--AFKSALY 786

  Fly   685 AYRRWAEKH--GPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITT------GVHSPSEF 741
            :|.:|...|  ..|..||..|.|...                .||.:..:|      |....|::
Worm   787 SYAKWQNDHHIHHEKTLPAFDSTDSM----------------RSLMLTFSTMFCSGEGSEPGSDY 835

  Fly   742 RVLGS--LSNMKDFAKDFHCPEGSPMNPVQKC 771
            ..:.:  ..|.:.|:..|:|...|.:...:.|
Worm   836 EAMINTVAENSRMFSIHFNCNNSSRLYNRRTC 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	134/723 (19%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:387391	104/542 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010