Protein Alignment Nep2 and nep-17

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001254395.1
• Gene: nep-17 / 174996
• WormBaseID: WBGene00010070
• Length: 1589
• Species: Caenorhabditis elegans
• Alignment Length: 815
• Identity: 206/815 - (25%)
• Similarity: 358/815 - (43%)
• Gaps: 141/815 - (17%)

  Fly    38 LWIGKVLRTSPPSNPQATALHGDSTTINQVP----TGTASKGKSGDSGDVCLTQECIHTASTVLR 98
            :|:..:..|        ..|....|.||.||    |.|.....:.....|....:.::||
 Worm   832 VWVSDIDTT--------FGLPNVKTDINVVPEAPITSTNVDKMNAYQMAVDYYAKSVNTA----- 883

  Fly    99 KMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKL---QEQLKDIITAERPETEPKH 160
                 ::|||:||.:|||.:.:         |:|.::..:..|   .::|:|........:.|.
 Worm   884 -----IDPCDDFYSYACGNFNQ---------SVSFYTARAQNLVYMAQKLEDPTYQTTINSSPA- 933

  Fly   161 FRLPNLLYKACM--------------NKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTW 211
            .:....||.||:              :|..|:|...:..|.:.:   .:.|:.|.:
 Worm   934 LKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQ---DFTLVNGGA--------- 986

  Fly   212 QEQVKKFRTAGFSMDYIIDFSIGVD-----------LQNSTKRLIDLDQSSLALSREYLVKGFNE 265
             .::...:..|.::.| :.|..|:|           :.||....:.:||::..||:.|......:
 Worm   987 -PKLPSAKQIGDALGY-LSFEQGIDTLISPLVDTYWIDNSKGYQMFIDQNTAYLSKTYYQPAAWK 1049

  Fly   266 TLVTAYYKYMVDIAVLFGANRDL---AKTELLLS--LEFEMALA-NISWPNEKRRNSSELYNLRT 324
            .....|.|..:|:...:...:::   |....|||  |::|..:| ..|..:..||.....:||..
 Worm  1050 IEKPKYLKMALDVVTRYAREQNITLPAGASDLLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTK 1114

  Fly   325 PAQLQAAYPYVQWVDYM----NALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMF 385
            .:.|...|.::.|:.|:    ||:..: :..|..::..:.|..........|.::|: ::.|.:|
 Worm  1115 TSDLVTKYNFMDWMTYLSHAPNAVKAK-ITDANYQVSVMEVDRLTHFSADYLQQSPE-LLVNLLF 1177

  Fly   386 WRIHGFSVGFLSEEFRKRQLQYATALSGRQEQ-----------------------EARWKECVDI 427
            .|:...:..::.        .||:|..|..::                       ||....|..:
 Worm  1178 VRLLLGNAQYIP--------SYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASV 1234

  Fly   428 ATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKE 492
            |.:.|      .|.:..:.|..:|.......:.:.:|..::..:.:.|..::|:::||...||::
 Worm  1235 ANNLM------QFANGRVFVDYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQK 1293

  Fly   493 AKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDI-DPDKYFESF---LGMNIFGTDYSFNKLR-LP 552
            |..|...:..:|.:||.:.::..|..||:.|.| |.|.:::.:   :..|||   ..:|:|. ..
 Worm  1294 AYAKTVQIQQNIAFPDWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIF---VQYNQLNAAQ 1355

  Fly   553 VNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDD 617
            .::||::  .:|..|||:|....|||.||||||...:||...|..:|:|.:|.|.|||:||||||
 Worm  1356 TDRTDFL--GQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGFDD 1418

  Fly   618 QGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTE-RATGLNLN---GINTQGENIADNGG 678
            ||.|:...|||..|...::...:...::|:|.:|..:.. .||..:.|   |..|||||||||||
 Worm  1419 QGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADNGG 1483

  Fly   679 VKESYIAYRRWAEKHGPEAKLPGL---DYTPEQMFWVAAGQTWCAKYR-KESLKMRITTGVHSPS 739
            |..::.||:......||:.:||..   .:|.:|:|:::..|.||...| .::|..:|....||||
 Worm  1484 VHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHSPS 1548

  Fly   740 EFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .:||.|::.|...|...|:||.||...|.|.||||
 Worm  1549 MYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	189/741 (26%)
nep-17	NP_001254395.1	M13	112..831	CDD:341056
		M13	884..1581	CDD:341056	189/741 (26%)