DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	255/762 - (33%)
Similarity:	393/762 - (51%)	Gaps:	74/762 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PQATALHGDSTTINQVPTGTASKGKS---------------GDSGDVCLTQECIHTASTVLRK-M 100
            |:|...:.|   ||:  |.|.|:.|:               |||       |....||.:|:| :
Worm    28 PRAPYFNDD---INK--TTTTSEDKTVGNTVVEEEKKTYTVGDS-------EGYQEASRLLQKSL 80

  Fly   101 KPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPN 165
            ...::|||:|:|:||..:::...||||..|.|.|:...:|:..:::.:..........|...|..
Worm    81 NLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLYEDNTSIPTSKSIALIK 145

  Fly   166 LLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADD-------SWTWQEQVKKFRTAGF 223
            .:|..||:......:|...:....:..|.||::..:.|....       |.|.|.:
Worm   146 QIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSR--------- 201

  Fly   224 SMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL---SREYLV--KGFNETLVTAYYKYMVDIAVLFG 283
            .:....||....|.:|.::||:..||.||.|   :|:|.:  |.: |..:.||.||.:.....:.
Worm   202 DVSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKY-EKQMKAYRKYTIGKVRYYT 265

  Fly   284 ANRDLAKTELLLS------LEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMN 342
            .:..:|..|..:.      :.||...|.|....|.|||.::|||:|....|:.....:.|.....
Worm   266 EDAGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNYTKLYNVRRFDDLKEYMSIIDWKKLTL 330

  Fly   343 ALLPEGLN--VAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQL 405
            :..|..::  :..:..|.:|...:.:.:..||..|..|::.||:..|..|.....:.:::...|.
Worm   331 STTPFLVHSYLKTNPSIIISDVEYLQKMNTLLQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQ 395

  Fly   406 QYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNE 470
            ::|..:.||::::.|||:||..|..           .|..:.||:||.|:|..::|...|:|:.:
Worm   396 EFAFQMYGRKQRQPRWKDCVSSAGG-----------KLSYASGSMYVRKYFDANAKNTTLDMITD 449

  Fly   471 IRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFL 535
            ::..|.:::...:||||:|||.|..|...|...|||||.:|::|||..:|..|:..|:..|...:
Worm   450 LQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKLDDWYKGLEGAPEDSFSQLV 514

  Fly   536 GMNI-FGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMN 599
            ..:| :..::.:.:|..|||:.:::..|  |:||||||...|:|.|||||||..||:|:.||.:|
Worm   515 EKSIQWRNNFYYRRLLEPVNRFEFISSA--AVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALN 577

  Fly   600 FGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLN 664
            :|.||.||||||||||||.|||||..|||||||...|...:..:.:||||||.:...|.|.|.:|
Worm   578 YGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRIN 642

  Fly   665 GINTQGENIADNGGVKESYIAYRRWAEKH-GPEAKLPGLD-YTPEQMFWVAAGQTWCAKYRKESL 727
            |..|||||||||||:|:::.||:.:.||| |.||:||..: .|.||:|:|...|.||.....|:.
Worm   643 GKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETK 707

  Fly   728 KMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .:.:.|..|||...||...|:|..:||:.|.||.||||||.::|.||
Worm   708 TLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	235/690 (34%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	236/696 (34%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	235/688 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.780