DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-26

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	203/749 - (27%)
Similarity:	354/749 - (47%)	Gaps:	103/749 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEE-NIPDD--KVSISTFSVISDKLQEQL 145
            |.::||:.|||.:|:::...||||||||:||||.::.:. |:..|  .....|.....|::.:.:
Worm   104 CTSEECVMTASRLLKRVDQSVEPCDNFYQFACGGWINQSVNLKYDSWNTLYETQRTAHDQIVQAM 168

  Fly   146 KDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGW-PLIKGDSWNADDSW 209
            ..|.....|.......|....:|:.||:...:|..|.....|..:.|||| |.:|..:...::|:
Worm   169 HKINDGSYPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELGGWMPELKNGALEQEESF 233

  Fly   210 TWQ--EQVKKFRTAGFSMDYII----DFSI------GVDLQ--NSTKRLIDL-DQSSLALSRE-- 257
            ..:  |..||.|.  |.::.||    ::|:      ||::.  ||.:.||.: :|..:.|:.|
Worm   234 EIELDEDEKKRRR--FEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLITIYEQLPILLAPEKY 296

  Fly   258 --------YLVKGFNE--TLVTAYYKYMVDIAVLFGANRDLAKTELLLS----LEFEMALANISW 308
                    .::.|..|  .:..|..:...:::.:.|.:....|..::::    ||:::.:|..::
Worm   297 HYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIANMIYLEYQITMAGSTF 361

  Fly   309 PNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLS-----VPSFFEDL 368
            ..||:    |.|.:....:||...|.:.|..:::.|:  |.|::..|.|.|.     :|.....:
Worm   362 YKEKK----ERYTVVMLRELQEIAPAINWHYFLSRLV--GENLSHSEPIALKTGTQWIPILSAIV 420

  Fly   369 GKL-LAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATAL-SGRQEQEARWKECV----DI 427
            .|| .:::...|:.||:.|:...|.:.:.|.:.|...|..|.:| ||...|  |.:.||    .|
Worm   421 EKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKCRDGLLWMAVSLYSGAASQ--RKEFCVLRLSGI 483

  Fly   428 ATSSMDEVCE--DDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVN-WMDAKT 489
            ...|:..:..  |..|             |..|:.|| ...:.:.|:..:.:::...| :.|.:|
Worm   484 FPLSLPSILRKIDGID-------------HTEKNVKA-VQNIADRIQEKYEEMVRSSNLFSDRET 534

  Fly   490 KKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSF----NKLR 550
            ::....|:::|...||:||.|..:.::.....:|.   |..|.|.    :.|:...:    .:||
Worm   535 RENVIDKVNNMTKFIGFPDAMRSDYEMEKEAVRLH---DTLFWSM----VLGSSSVYKERLQRLR 592

  Fly   551 LPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGF 615
            |||:...|| ..||||....::...|.:|.|...|:..:.:..:..:.|:..||.:||||:||.|
Worm   593 LPVDPRSWV-DTRPAISVPAHNYERNLVQIPFDSLRLPYADEHQLDFANYAGIGTIIGHELTHAF 656

  Fly   616 DDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQG--ENIADNGG 678
            |.||:.....|||..||..|:.:.:.|:.:|.::||....:   ..::|... :|  |||||..|
Worm   657 DGQGKLHGPTGNLGVWWSTDSIREFKAREQCFVKQYAGLMD---SHDMNAAK-EGLYENIADQVG 717

  Fly   679 VKESYIAYRRWAEKHGPE--AKLPGLD-YTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSE 740
            :|   :||..| :.:|.:  .::|||: |:.:|:|::|..|.||| .|.:|.|::    .|....
Worm   718 LK---VAYEAW-KSNGNQNSGRMPGLEKYSQDQLFFLAYTQGWCA-LRSKSYKLQ----PHMEER 773

  Fly   741 FRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .|:||||.|..:||..:.|...|.|||..||.:|
Worm   774 IRMLGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	194/725 (27%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	199/740 (27%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	194/725 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970