Protein Alignment Nep2 and nep-5

DIOPT Version :9

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 156/732 - (21%)
• Similarity: 286/732 - (39%)
• Gaps: 189/732 - (25%)

  Fly    84 CLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDI 148
            |.|:||:..::.:|..|...|.||:||:...|..:...:                 |..|:|..:
 Worm   108 CQTKECVKYSAELLELMDSSVNPCENFHHHVCNGFNPRK-----------------KDFERLMKL 155

  Fly   149 ITAERPETEPKHFRLPN----LLYKACMNKTLIETLGPEPITRVAERLGG-------WPLIKGDS 202
            |..:.   :|.|.:..|    :|.|..|.||       |.|.:|. ||..       :||:
 Worm   156 INIQE---KPDHRKAVNVVRRMLSKCAMGKT-------EEIHQVG-RLSSIILPGLPFPLL---- 205

  Fly   203 WNADDSWTWQEQVKKFRTAGFSMDYIIDF----SIGVDLQN-STKRLIDLDQSSLALSREYLVKG 262
               ::|||  :......|:..|..|...|    ...:.|.| .....:.:..||.:....::||.
 Worm   206 ---NNSWT--KPSDPISTSNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFVVKP 265

  Fly   263 FNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTP-- 325
            |:..|....::.|.||   ...|...:.|..::.|||           :::|..:::..|:|.
 Worm   266 FSPVLTNFKFRNMYDI---LKRNAPESSTNGMIDLEF-----------DRQRQLNDVIKLQTKLE 316

  Fly   326 -------------AQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPK 377
                         .::|...|.:.|...:::.:|.|....::::...:. |::|::..:::.||.
 Worm   317 KIEFKADPEVVNLTEIQRQMPIIDWKRLIDSWIPNGYAHLKEKVYGFNT-SYYEEINAIISSTPS 380

  Fly   378 RVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDS 442
            ..|.|::|.|   ||..||..|                            ..|.:::.|   ...
 Worm   381 ETIYNFLFLR---FSFKFLRTE----------------------------VASDLEDTC---LHQ 411

  Fly   443 LGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDE----VNWMDAKTKKEAKLKLHSMATH 503
            |..::....|   .:...:..||.::|.:.:...|.|..    :.|||::..:||:.|.:...|.
 Worm   412 LSTTIPGKIV---LYGSEEPEALNLLNGMLHTIKDQLKRSLATLKWMDSRGIEEAQKKFNKTKTV 473

  Fly   504 IGYPDEMLDNEKLAAYYAKLDIDPD-KYFESFLGMNIFGTDYSF-----NKLRLPVNKTDWVRHA 562
            .|:..|.|.:|.:.      .|.|: .|..:...:.::.|...|     |.:.:.:|.
 Worm   474 FGFTGEDLIDELVG------KITPESNYISTLQNVLLWQTRNMFKSVAENNVTVFLNS------- 525

  Fly   563 RPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGN 627
                 ..|||..:|.|.....:|...|.:|..|.|.||..|...|..::.|.||::||.:|..||
 Worm   526 -----EVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDGN 585

  Fly   628 LRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEK 692
            .|:||:.:|::.:    :.|::.:....:...|:::    :.|.|..|:  .||.|
 Worm   586 HRNWWNTETERYF----QIIVQCFDGMMQNVFGVSV----SIGWNAYDS--TKEPY--------- 631

  Fly   693 HGPEAKLPGLDY-TPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKD 756
                |.|||:.. :.|.:|:.:..:|.|            |:...:.:|     :|:::..|...
 Worm   632 ----ATLPGIQQSSDEALFFYSMVKTMC------------TSDPDNVNE-----ALASVPQFNSA 675

  Fly   757 FHCPEGSPMNPVQKCEV 773
            |.|..|:.|||..||::
 Worm   676 FKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	149/709 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	149/709 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920