DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and nep-11

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	286/826 - (34%)
Similarity:	434/826 - (52%)	Gaps:	103/826 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WWRRRNKLEKSLLVSLGIMFVVLA---------------------------TGFGLWIGKVLRTS 47
            ||:.|..:||.||..| ::|.:|.                           .|||         .
Worm    65 WWKSRTTMEKLLLPVL-LLFCLLTAVLLAVIINTDKRIEAMKTDHATQTEHAGFG---------D 119

  Fly    48 PPSNPQATALHGDSTT---INQVPTG-----TASKGKSGDSGDVCLTQECIHTASTVLRKMKPEV 104
            |..||..||  .|...   :.:.||.     |.|..|..:. :||.|..|:..|:..|..|...|
Worm   120 PTENPTKTA--EDPRVPPIVPEAPTSPEPEVTTSTEKPKEP-EVCSTPGCVRAATHFLNAMNTSV 181

  Fly   105 EPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERPETEPKHFRLPNLLYK 169
            :|||:|:|||||.:.::..||||.....||:...:::::||: ::..:...||.:...:....|:
Worm   182 DPCDDFFEFACGQWNDQHPIPDDMYGFGTFAYAREQVRQQLR-VLLEQEVVTESESINMARATYR 245

  Fly   170 ACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAG--------FSMD 226
            :|||||.::.|...|:......||.|||:: ::|:.          .||....        :.:|
Worm   246 SCMNKTQLDELMTGPLFETLTELGEWPLLQ-ENWDK----------TKFNFTSLLVNSRRDYGVD 299

  Fly   227 YIIDFSIGVDLQNSTKRLIDLDQSSLAL---SREYLVKGFNETL----VTAYYKYMVDIAVLFGA 284
            ......|..|.:|:::..:.:|||:|||   :|:|.:   |.||    :|||.||:..||.|...
Worm   300 VFFQLYIYADSKNTSRNTLFIDQSTLALGRGTRDYYL---NTTLFSSHMTAYRKYLRQIAHLLKT 361

  Fly   285 NRDLAKTELLLS------LEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNA 343
            :.:|.::|..::      ::||:.||.|....::|||::.|||.|....|....|.|.||.:..:
Worm   362 DGNLTRSESEMNADIEKIIDFEIELAKIIVAEDERRNNTRLYNKRQIQDLYNLLPQVDWVPFFQS 426

  Fly   344 LLPEGLNVA---EDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQL 405
            :.|..|...   |.|:|...: .:.:.:.:|:.||...::.||:.||:...:|.:|.|.|...:.
Worm   427 IAPSDLTHLFHNETEIIICEI-EYLQHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDERFEDIKQ 490

  Fly   406 QYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNE 470
            .:...::|:|:...|||:|..:.::           .|.::.|::||..||.:..|..||.|:..
Worm   491 DFLKVMTGQQQSPPRWKDCAQVPST-----------VLPLAAGAIYVQAHFQESDKHEALRMIMH 544

  Fly   471 IRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDI-DPDKYFESF 534
            :||.|.|::.:.:|||.:||..|..|.:||..:|||||...|..||...|..|.| |.|.|:...
Worm   545 LRNSFADLVRQNDWMDEETKAVAIEKANSMINNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYIM 609

  Fly   535 LGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMN 599
            ....::.....|.||..|.:|.::  ...||:||||||..:|:|.|||||||..||:...||.:|
Worm   610 KKSVVWMQSREFQKLTKPFDKHEF--DISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVN 672

  Fly   600 FGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLN 664
            :||||.||||||||||||||.|:|..|||.:||...:..::..:.:||:|||||||...|...:|
Worm   673 YGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTNFRVN 737

  Fly   665 GINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGL-DYTPEQMFWVAAGQTWCAKYRKESLK 728
            |..||||||||||||||::.||:::..::|.|.:|||| .||.||:|:|:....||.|.::.:..
Worm   738 GKLTQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAM 802

  Fly   729 MRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .::.|..|||..|||:|.||||:.||..:.||..:|:||..||.||
Worm   803 QQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	252/693 (36%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	255/702 (36%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	251/692 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.880