Protein Alignment Nep2 and nep-13

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001342017.1
• Gene: nep-13 / 173672
• WormBaseID: WBGene00018196
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 822
• Identity: 192/822 - (23%)
• Similarity: 333/822 - (40%)
• Gaps: 200/822 - (24%)

  Fly    22 LVSLGIMFVVLATGFG----LWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGD 82
            |:|:.|..|::|...|    .|       ...|.|||..                 |.....:.|
 Worm    42 LISIIICLVIIAICMGAVIVFW-------RMDSAPQAIC-----------------KTDHNKTRD 82

  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQ--L 145
            ||.|.|||..:||:|......::||::|||::||.|  :|:..:|.:..:....|..||..|  |
 Worm    83 VCKTAECITLSSTLLNWQNTNIDPCEDFYEYSCGRY--QEHTLNDGIRANEKDTIVMKLIRQFVL 145

  Fly   146 KDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAER--------LGGWPLIKGDS 202
            |:..|....|....      |||:.|..:..:|....|  |.|.:|        :|.||:
 Worm   146 KNQSTTSNSENALM------LLYEKCSLRYRMENRHQE--TEVIQREVFENIRKIGSWPI----- 197

  Fly   203 WNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDL---------------QNSTKRLIDLDQSSL 252
              ||.:|         .::.|:::.::.....:.:               .|:|.:.:.:..:.|
 Worm   198 --ADKNW---------NSSHFNLNNMLSNMASIHMLPFGLFETRVIELYPMNTTAKQLVIRPTKL 251

  Fly   253 ALS--REYLVKGFNETL----VTAYYKYM-VDIAVLFGANRDLAKTELLLSLEFEMALANISWPN 310
            ..|  :|.||:...:.|    :|:..|.: .|:|..|..::::....:              .|.
 Worm   252 KFSIPQEELVRAIRDLLSVNGITSIMKKVKEDVAESFALDKEIGNIHI--------------DPQ 302

  Fly   311 EKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSF---FE------ 366
            .|....||         ||.|.|.:.:    ..::...||.......:|....|   ||
 Worm   303 PKPATLSE---------LQKAVPDIDF----ERIIKSYLNPKTGNWSSLRTKIFSARFELFFGKN 354

  Fly   367 -DLGKLLAKTPKRVIANYMFWRIHGFSVGFL--------SEEFRKRQLQYATALSGRQEQEARWK 422
             :|..::|:|..|::|||:|.:...::..|.        .::|
 Worm   355 NNLSSIIARTKPRILANYLFLKYIEYAYFFFFDNTKVFSDDDF---------------------- 397

  Fly   423 ECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDA 487
             |.::.|:|:...      ||.:     :|..||.|::.|.|.|:|..::..:.:|::...|:..
 Worm   398 -CTEVVTTSLPRA------SLRV-----FVRNHFKKENMAVASEIVEVVKTAYVEIINNSTWLHN 450

  Fly   488 KTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDID-PDKYFESFLGMNIFGTDYSFNKLRL 551
            .|::.|..|:..|...|||.:|......|...:..|.:. .|.:|.....:|.|    ...:|..
 Worm   451 STRESAIEKVVKMKKVIGYTEEYERTGALDEMFETLQLSRSDSFFVLMTKVNRF----KIEQLMD 511

  Fly   552 PVNKTDWVRHARPAIV-NAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGF 615
            .|:....:....|.:: ||||...:|.:......|....|:.:.|:|:....:|.|:.|||.|.|
 Worm   512 FVSSDSLLNPIEPLVMANAFYFPTKNLLNVLVPFLDKPLFDFKYPRYVAMAGVGRVLAHEIGHAF 576

  Fly   616 DDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVK 680
            |..|||.|..|..||||..:..:.|..:::|..||:.|:.:.:.....||.....|.|||..|::
 Worm   577 DINGRQTDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAEIIADALGME 641

  Fly   681 ESYIAYRRWAEKHGPEAKLPGLDYTPEQ------------MFWVAAGQTWCAKYR-KESLKMRIT 732
            .|:||:::             ::.|.||            :::..|...:||..| :|....:::
 Worm   642 ASWIAFKK-------------INLTEEQGLIQFEDHDFGKLYFQVAALDFCAPSRIEERYSDQLS 693

  Fly   733 TGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
               |..::||:.|:.||.:.||..:.||.||.|||||:|:::
 Worm   694 ---HPTNKFRINGAFSNSRAFADTYKCPVGSKMNPVQRCDMF 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	169/732 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:341056	169/731 (23%)