Protein Alignment Nep2 and Nep4

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 807
• Identity: 274/807 - (33%)
• Similarity: 420/807 - (52%)
• Gaps: 121/807 - (14%)

  Fly    66 QVPTGTASKGKSGDSGDVCLTQECIHTASTVLRK--MKPEVEPCDNFYEFACGTYLEEENIPDDK 128
            |:|....|.|...|...   :.|.:..|...:.|  |.|:.:|||:||::|||.:.....||.||
Mosquito   224 QLPRVRRSVGWMNDDRS---SPESVRAAQVAIMKQYMDPDADPCDDFYQYACGNWDRVNPIPKDK 285

  Fly   129 VSISTFSVISDKLQEQLKDIITAERP-------------ETEP---------------------- 158
            .::.||.::.:.|...||.::....|             .::|
Mosquito   286 AALDTFELLRESLDLVLKQLLLEGEPAGLLDVENALSTVRSQPDGTKKSTSTTTTAASAGWPTTT 350

  Fly   159 --------------KHFRLPNL---------------------------------------LYKA 170
                          |..|..|.                                       |:.:
Mosquito   351 VTGGPAQQQLHRVRKRGRAENRNRSGRAVQNKLIIRSAQVKRVRRKRELLINDDAEMKARHLFVS 415

  Fly   171 CMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGV 235
            |||..|||..|.||:..:...|||||:::..:|: :.|:.|.......|.  ::.|.:|...:|.
Mosquito   416 CMNYELIERRGLEPLRTLLHSLGGWPVLEPHTWD-ESSFDWLNLTAALRR--YNNDVLIVEWVGP 477

  Fly   236 DLQNSTKRLIDLDQSSLAL-SREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEF 299
            |::||.:.::..||:||.| :|:|.::..|...:.||.::|:::..|.....|.|:......:||
Mosquito   478 DIKNSDENIVQFDQTSLGLPTRDYYLQPGNRKYLEAYRQFMLEVIGLLDVPADTARQATDEMIEF 542

  Fly   300 EMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSF 364
            |..||||:...|:|.|.|.||......|||...|.:.|..|:..:....:|  ....:.:...|:
Mosquito   543 ETQLANITSTPEERNNVSTLYRKLMLDQLQEEVPQINWTHYLTIVTERPVN--GSSFVVMFAMSY 605

  Fly   365 FEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIAT 429
            ..||.:|:.:|..|::|||:.||.....:..|.:.|...:.:::.||.||:....|||.||....
Mosquito   606 MRDLVELIDQTEPRIVANYLLWRFVRHRINNLDDRFLGAKQRFSNALFGRERNPPRWKNCVTQVN 670

  Fly   430 SSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAK 494
            ::|           |::||:::|.::|.::||.:.|.|.:|:::.|.:||....|:|..|::.|:
Mosquito   671 ANM-----------GMAVGAMFVRRYFDENSKRDTLTMTHELQDAFREILGRTGWIDMATRQLAE 724

  Fly   495 LKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGM--NIFGTDYSFNKLRLPVNKTD 557
            .|:::|:..|||||.:||.|:|:|.||.|:|.||:|||:.|.:  :|..||.  .||..|||||.
Mosquito   725 QKVNAMSLRIGYPDFILDPEQLSARYATLEIHPDRYFENTLNVLSHIRRTDQ--EKLGQPVNKTA 787

  Fly   558 WVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQF 622
            |  |..||:|||:||..:|.|.|||||||..|::...||.:|:|.||.|||||:||||||:||.|
Mosquito   788 W--HTAPAVVNAYYSRNKNQIMFPAGILQPPFYHRHLPKAINYGGIGVVIGHELTHGFDDKGRLF 850

  Fly   623 DVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYR 687
            |..|||..||.....:.:..:|.|::||||.|......:.|:|.||||||||||||:|::::||.
Mosquito   851 DRDGNLYRWWSDRAIEEFHERAACLVEQYGRYRIAEVDVQLDGENTQGENIADNGGIKQAFLAYS 915

  Fly   688 RW----AEKHGPEAK-LPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSL 747
            :|    .::...||: ||||:.|..|:|::...|.||...|.|:.:.::.|.||||..|||:|:|
Mosquito   916 KWLAAQTDRRVLEAETLPGLNVTRTQLFFLNFAQIWCGAMRPEATRNKLKTAVHSPGRFRVIGTL 980

  Fly   748 SNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ||.:|||:::|||.||.|||..||.||
Mosquito   981 SNSEDFAREYHCPVGSTMNPPGKCSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	261/763 (34%)
Nep4	XP_061501026.1	None