DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Gm49333

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	764	Identity:	257/764 - (33%)
Similarity:	404/764 - (52%)	Gaps:	72/764 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVSLGIMFVVLATGFG----LWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGD 82
            ||..|::.|:.|...|    ||:                 |.|                  .:..
Mouse   208 LVLAGLILVLAALLLGCLVALWV-----------------HRD------------------PAHS 237

  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKD 147
            .|:|:.||..|..:|..:...|.||.:||:|:||.::....:|:.:...:||:.:.|:.|..||.
Mouse   238 TCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKH 302

  Fly   148 IITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQ 212
            ::......:..:..|.....|.:|:....||.||.:|:..:.:::|||.:.  ..|:.|   ::.
Mouse   303 LLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNIT--GPWDED---SFM 362

  Fly   213 EQVK----KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLVKGFNETLVTAY 271
            :.:|    .:|...|...|     :..|.::|...:|.:|||.|.| ||: ||.:..||.::|||
Mouse   363 DVLKAVAGTYRATPFFTVY-----VSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAY 422

  Fly   272 YKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQ 336
            ..|||::.||.|......:.::...||.|:.||||:.|.::||:..::|:..:.::|||..|.|.
Mouse   423 LDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVD 487

  Fly   337 WVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFR 401
            |:::::.|| ..|.:.:.|.:.:....:.:.:.:|:.:|...::.||:.|.:...:...|.:.|.
Mouse   488 WLEFLSFLL-SPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFE 551

  Fly   402 KRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANAL 465
            ..|.:....|.|.::. ..||:.|:    |:.|       |:||.::|||:|...|.:.||..|.
Mouse   552 TAQEKLLETLYGTKKSCTPRWQTCI----SNTD-------DALGFALGSLFVKATFDRQSKEIAE 605

  Fly   466 EMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKY 530
            .|:||||:.|.:.|.::.|||.||:..||.|..::...||:||.:|:.::|...|...::..|.:
Mouse   606 GMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSF 670

  Fly   531 FESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRP 595
            |::.|.:..|......::||.|.::..|  ...|..|||:|...:|.|.|||||||..|:....|
Mouse   671 FQNMLNLYNFSAKVMADQLRKPPSRDQW--SMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHP 733

  Fly   596 KYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATG 660
            |.:|||.||.|:|||:||.||||||::|.:||||.||..::..|:.....|:.|||..|  :..|
Mouse   734 KALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQY--QVNG 796

  Fly   661 LNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKE 725
            ..|||:.|.|||||||||:|.:|.||:.|..|||.|..||.:..|..|:|:|...|.||:....|
Mouse   797 ERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPE 861

  Fly   726 SLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |....:.|..|||:.|||||:|||.:||.:.|.||.||||||.|.||||
Mouse   862 SSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	237/674 (35%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	234/678 (35%)
		M13	259..908	CDD:189000	237/674 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830