DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Ece2

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	764	Identity:	257/764 - (33%)
Similarity:	404/764 - (52%)	Gaps:	72/764 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVSLGIMFVVLATGFG----LWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSGDSGD 82
            ||..|::.|:.|...|    ||:                 |.|                  .:..
Mouse    61 LVLAGLILVLAALLLGCLVALWV-----------------HRD------------------PAHS 90

  Fly    83 VCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKD 147
            .|:|:.||..|..:|..:...|.||.:||:|:||.::....:|:.:...:||:.:.|:.|..||.
Mouse    91 TCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKH 155

  Fly   148 IITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQ 212
            ::......:..:..|.....|.:|:....||.||.:|:..:.:::|||.:.  ..|:.|   ::.
Mouse   156 LLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNIT--GPWDED---SFM 215

  Fly   213 EQVK----KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLVKGFNETLVTAY 271
            :.:|    .:|...|...|     :..|.::|...:|.:|||.|.| ||: ||.:..||.::|||
Mouse   216 DVLKAVAGTYRATPFFTVY-----VSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAY 275

  Fly   272 YKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPYVQ 336
            ..|||::.||.|......:.::...||.|:.||||:.|.::||:..::|:..:.::|||..|.|.
Mouse   276 LDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVD 340

  Fly   337 WVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFR 401
            |:::::.|| ..|.:.:.|.:.:....:.:.:.:|:.:|...::.||:.|.:...:...|.:.|.
Mouse   341 WLEFLSFLL-SPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFE 404

  Fly   402 KRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANAL 465
            ..|.:....|.|.::. ..||:.|:    |:.|       |:||.::|||:|...|.:.||..|.
Mouse   405 TAQEKLLETLYGTKKSCTPRWQTCI----SNTD-------DALGFALGSLFVKATFDRQSKEIAE 458

  Fly   466 EMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKY 530
            .|:||||:.|.:.|.::.|||.||:..||.|..::...||:||.:|:.::|...|...::..|.:
Mouse   459 GMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSF 523

  Fly   531 FESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRP 595
            |::.|.:..|......::||.|.::..|  ...|..|||:|...:|.|.|||||||..|:....|
Mouse   524 FQNMLNLYNFSAKVMADQLRKPPSRDQW--SMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHP 586

  Fly   596 KYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATG 660
            |.:|||.||.|:|||:||.||||||::|.:||||.||..::..|:.....|:.|||..|  :..|
Mouse   587 KALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQY--QVNG 649

  Fly   661 LNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKE 725
            ..|||:.|.|||||||||:|.:|.||:.|..|||.|..||.:..|..|:|:|...|.||:....|
Mouse   650 ERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPE 714

  Fly   726 SLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |....:.|..|||:.|||||:|||.:||.:.|.||.||||||.|.||||
Mouse   715 SSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	237/674 (35%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	237/674 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930