DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and kel

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	856	Identity:	169/856 - (19%)
Similarity:	302/856 - (35%)	Gaps:	190/856 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTVIQNPNWWRR----------RNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQAT 55
            :|.::..|....|          :.|..:.||....:.....|.|.|::          |:.|.|
Zfish     9 LQEMVTTPEQQPRSDEPNPVLCNKYKYRRLLLPPFAVSLFATALGLGIY----------SHLQKT 63

  Fly    56 ALHGDSTTINQVPTGTASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLE 120
            |            ....||.||  :..:||:..||..:......|.|...||| ::.||||....
Zfish    64 A------------DPWKSKWKS--AAPLCLSPACIRASEHFSVAMDPFSRPCD-YFLFACGAGGS 113

  Fly   121 EENIPDDKV------------------------------SISTFSVISDKLQEQLKDIITAE--- 152
            ..|....:|                              .:.||......|...:|:|:.|.
Zfish   114 STNRDRQRVKGEVNKHSEVRTRGLIEMRRGTDGWSKSDGQLKTFPDRQTALLTAIKEILEAPDEA 178

  Fly   153 ----RPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADD-SWTWQ 212
                ..|.:.|:|      :|:|||....|.:|.||...:.::||||.:  ...||..| :.|..
Zfish   179 VSMGAAEQKAKNF------FKSCMNAESREKMGSEPFLTLLQQLGGWAV--SGVWNQTDFNSTLA 235

  Fly   213 EQVKKFRTAGFSMDYIIDFSIGV------DLQNSTKRLIDLDQSSLALSREYLVK----GFNETL 267
            ..:.::.|..|       |::.|      :...|.:..|.:|:.......|:..|    ..|...
Zfish   236 LLMGQYSTFPF-------FNVYVGPEPSEEQSASNRHYIQIDEPHFQFPIEWNSKTQKAKANTRY 293

  Fly   268 VTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAY 332
            :..:|.......||.|...|.......|.:.....||..::|...|.:...||...|..:||...
Zfish   294 LRPFYSACGQYLVLLGVPSDRTTQHCGLFVSLSTTLAVATFPLPYRLSQKLLYRRTTIQELQTLA 358

  Fly   333 PYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGK----------LLAKTPKRVIANYMFWR 387
            |.|.|:..:.|.. :.|.:::.:::.:....:...:.|          |:...|   :..||.:.
Zfish   359 PAVDWLACLQATF-QPLLISKSDIVLVHNLPYIIHMSKTIHLWQVQHELMGTGP---LNTYMIFS 419

  Fly   388 IHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYV 452
            :....:..|...|.:....|:.|....||. ..|..||        :..|..||:|   :.....
Zfish   420 LLQTLIPALDSRFFQIMRNYSIATGDTQEM-PHWWRCV--------QQTERGFDTL---LSHAIR 472

  Fly   453 GKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLA 517
            .||..|:::    |::.::.:.....|.:::|.|.|.......|::|:...|......|...:|.
Zfish   473 EKHAQKEAE----ELIQDVYSSLKKKLTDLSWRDEKESDFILNKINSLNPRISTNTNNLSYTELN 533

  Fly   518 AYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPA 582
            ..|.|:.::.:.:|.::|.:.:.........|.|. .:|:.:.      :..|.|.  |.|..|.
Zfish   534 HLYEKVILNEEDFFSNYLQILLLEQKSRARLLSLG-TQTEGLS------MTPFISG--NDIIVPV 589

  Fly   583 GILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWW----HPDTQKAYLAK 643
            |:....||::..|:.:|:|.:|.::..::.|..            |.|.:    :|:|:
Zfish   590 GMFVSPFFHSSYPRALNYGTLGSLMAKDLLHLL------------LPDIYTKAKNPETE------ 636

  Fly   644 AKCIIEQYGNYTERATGLNLNG----------INTQGENIADNGGVKESYIAYRRWAEKHGPEAK 698
            :.|:...|.:.|:        |          .:.|.|.......::.:..||:...:::..::.
Zfish   637 SLCVWSHYLSVTK--------GPGWGDAFYLPSSKQQEVWVQYSALQVALDAYKMSFKRYLADSS 693

  Fly   699 LPGLDYTPEQMFWVAAGQTWC--AKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPE 761
            |||..|.  .:|..:..:..|  ..|| |.:.:       .|| |.|....||.....|...|..
Zfish   694 LPGFSYV--HLFLSSFTKVTCDTDAYR-EFMPL-------EPS-FLVTVLCSNSGLCPKPLTCMN 747

  Fly   762 GSPMNPVQKCE 772
            .....|.:.|:
Zfish   748 KPQSFPAEMCQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	145/741 (20%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	114/565 (20%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	32/166 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020