DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep2 and mme

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	251/790 - (31%)
Similarity:	409/790 - (51%)	Gaps:	95/790 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEKSLL---VSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTASKGKSG 78
            |||.|:   :.|||:.:.:...:                                 .|::.|
Frog    20 LEKGLIILCIFLGIISIAMILAY---------------------------------ATSNDG--- 48

  Fly    79 DSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQE 143
                :|.:|.||.||:.::..|....:||::||::|||.:|::..|||:.:..:||.::...::.
Frog    49 ----ICTSQACISTAARIIANMDAATDPCNDFYQYACGGWLKKNRIPDNNIVSNTFDILRTDIEV 109

  Fly   144 QLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDS 208
            .|||.:..|..:..|. .:.....||:|:::|:.......|:.:....|..|| |..|:|.....
Frog   110 VLKDALEKESADDIPA-IKKVKTFYKSCIDETIKNLRKGGPLIKTLPALYDWP-IAVDNWETRYG 172

  Fly   209 --WTWQEQVKKFRTAGFSMDY----IIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYL-VKGFNE 265
              |:.||.:     |||...|    :|:..:..||.||:..::.:||..|.| |::|. .||.:|
Frog   173 LVWSAQESI-----AGFITKYGQSGLINVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSE 232

  Fly   266 TLVTAYYKYMVDIAVLFGANRD--------LAKTELLLSLEFEMALANISWPNEKRRNSSELYNL 322
            ....||.:.||.:|:|....|:        |::.|.:..||.|:|.|..|  .|.|.|.:::|..
Frog   233 IACLAYMEQMVSVAMLIRKERNLTINEDKILSEMEKVFKLEREIAKAEAS--EEIRENLNDIYKK 295

  Fly   323 RTPAQLQAAYPY------VQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVI 380
            .|.:.:...||.      :.|:..:||:: |.|:::.|:|.:.|....:.:.| :.|.|...|.:
Frog   296 MTLSGIAKTYPLKMNDQNINWLKLINAIISPGGVSIEENEQVALICSDYLKKL-RFLNKYKAREL 359

  Fly   381 ANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGI 445
            .||:.||....::..||.|::...:....||.|...:.:.|:.||.....:|::
Frog   360 QNYLGWRYILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQTCVTYLNDNMED----------- 413

  Fly   446 SVGSLYVGKHF-----HKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIG 505
            ::|.||:.:..     |...|....|::.|||..|.::|:|::|||..|||.|..|:.|:...|.
Frog   414 AIGRLYLKETLSADIEHVKVKDKVKEIIAEIRRAFLEMLEEMDWMDEDTKKRAARKVASINERIA 478

  Fly   506 YPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAF 570
            :.::::|:.||...|::|:...|:.||:......|......::||..|||.:||  ..||.||||
Frog   479 FSEDIMDDFKLNEGYSELEFRVDELFENKQKYIEFVQKKMTSRLRKQVNKNEWV--PGPAHVNAF 541

  Fly   571 YSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPD 635
            ||...|.|.|||||||..||::.:|..:|:|.||.:||||||||||::|..||..|||.:||...
Frog   542 YSLTYNEIVFPAGILQTPFFSSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNA 606

  Fly   636 TQKAYLAKAKCIIEQYGNYT-ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKL 699
            :...:...::|.:.|||||: :.|.|..||||:|.||||:||||::.:|.|::.:.:.|..:..|
Frog   607 SMMNFSNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSHKEDDLL 671

  Fly   700 PGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSP 764
            ||:|...:|:|:::.||.||..:|.|.....|.||.|:|..|||:|:|.|..:|:|.|.|...:.
Frog   672 PGIDLDSDQLFFISFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAY 736

  Fly   765 MNPVQKCEVW 774
            |||..||::|
Frog   737 MNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	233/696 (33%)
mme	XP_031758820.1	M13	71..744	CDD:341056	233/695 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030