Protein Alignment Nep2 and phex

DIOPT Version :10

• Sequence 1: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_004911718.1
• Gene: phex / 100496470
• XenbaseID: XB-GENE-1012247
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 730
• Identity: 259/730 - (35%)
• Similarity: 396/730 - (54%)
• Gaps: 50/730 - (6%)

  Fly    73 SKGK-SGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSV 136
            |||. |....:.|||.|||..|:::..||...|:|||:|:::|||.::||..||||..:...:..
 Frog    43 SKGLISFQKDEYCLTPECIEAAASIRSKMNLSVDPCDDFFQYACGGWIEENPIPDDMSNYGIYPW 107

  Fly   137 ISDKLQEQLKDIITAERP---ETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLG-GWPL 197
            :...:..:||.::  |:|   ..:.:..:.....|.:|||:|.||....:||.::.::.. .||:
 Frog   108 LRTNVDLKLKALL--EKPISKRRDSEAIQKVKTFYISCMNETQIEEDDIKPILKILKQPSLRWPV 170

  Fly   198 IKGDSWNADDSWTWQEQVKKF-RTAG-----FSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-- 254
            ::.   |......|.|:...| :|..     :|....:...:.:|.:.|...::.|||:||:|
 Frog   171 LES---NIGSDGKWSERKFSFLQTVADLRRLYSTSVFLRVYVAIDDKVSNNFILKLDQASLSLLS 232

  Fly   255 SREYLVKGFNETLVTAY----YKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRN 315
            ..:||   .|.|:...|    .::|||:|||.|||:..|:|::...:|.|..||.|:.|.| .|.
 Frog   233 HEDYL---DNSTIAKKYRDALLEFMVDVAVLLGANKTRAETDMKALIELETKLAQITVPQE-NRT 293

  Fly   316 SSELYNLRTPAQLQAAYPYVQWVDYMNALL-----PEGLNVAEDEMINLSVPSFFEDLGKLLAKT 375
            |..:||....::|.|..|...|:.|:..::     ||..|:...|.:.:.||..|:||..::...
 Frog   294 SEMMYNKMNISELSAMIPQFDWLSYLKNIIDFNIYPELKNIDLSENVIVRVPQHFKDLFNIIESE 358

  Fly   376 PKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDF 440
            .||.:|||:.||:....:..||..|:.|||::|..|.|......||..||:...
 Frog   359 EKRTLANYLIWRLVYSRIPNLSRRFQYRQLEFARILLGTNSLAGRWDRCVNYVE----------- 412

  Fly   441 DSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEVN-WMDAKTKKEAKLKLHSMATHI 504
            :|:...||.|:|..||.:|.|....|:|:.||..|.|:|::.| ||||:||.:||.|..::...:
 Frog   413 NSIPYPVGKLFVDAHFQEDKKDMMEELVDGIRWAFIDMLEKENDWMDAETKIKAKQKAVTVMAKV 477

  Fly   505 GYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNA 569
            |||:.:.::..|......|......||.:.|....|.:...|..||..|.|.:|  ...|..|||
 Frog   478 GYPEFLFNDTYLNEDIKMLKFSESDYFGNVLQTLHFISQSDFYWLRRNVPKKEW--FTNPTTVNA 540

  Fly   570 FYSSLENSIQFPAGILQGHFF-NAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWH 633
            |||:..|.|:||||.||..|| ..|.|:.:::||||.::|||.|||||:.||::|.:|||..||.
 Frog   541 FYSASTNQIRFPAGELQKPFFWGVQYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKEGNLFSWWT 605

  Fly   634 PDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAE---KHGP 695
            .::::.:..|..|::|||.||..:..||::.|:.|..||||||||::||:.|||:|.|   |...
 Frog   606 SESEERFKNKTLCMVEQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRAYRKWIEDLRKGKE 670

  Fly   696 EAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCP 760
            |..|||||....|:|:::.....|..:|.||.:.:|..|||||.:|||:|::||.::|.|.|.||
 Frog   671 EMLLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAMSNFEEFHKAFSCP 735

  Fly   761 EGSPMN-PVQKCEVW 774
            :.|.|| ....|.||
 Frog   736 KDSKMNRGANSCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:341056	243/694 (35%)
phex	XP_004911718.1	M13	75..741	CDD:341056	241/687 (35%)