DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3f1 and EIF3F

DIOPT Version :9

Sequence 1:	NP_649489.1	Gene:	eIF3f1 / 40587	FlyBaseID:	FBgn0037270	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_003745.1	Gene:	EIF3F / 8665	HGNCID:	3275	Length:	357	Species:	Homo sapiens

Alignment Length:	277	Identity:	133/277 - (48%)
Similarity:	190/277 - (68%)	Gaps:	18/277 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRVHPVVLFQVVDAFERRNADSHRVIGTLLGSVDKGVVEVTNCFCVPHKEHDDQVEAELSYALDM 72
            ||:|||:|..:||::||||..:.||||||||:|||..|||||||.|||.|.:|:|..::.:|.:|
Human    92 VRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNM 156

  Fly    73 YDLNRKVNSNESVVGWWATGNDVTNHSSVIHEYYARECNNPVHLTVDTSLQGGRMGLRAYVCIQL 137
            |:|::||:.||.::||:|||:|:|.||.:|||||:||..||:|||||||||.|||.::|||...:
Human   157 YELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLM 221

  Fly   138 GVPGGKSGCMFTPIPVELTSYEPETFGLKLLQKT-------VGVSPAHRPKTVPPMLDLAQISEA 195
            ||||...|.||||:.|:...|:.|..|:.|:.||       :|:|.           ||.|:..|
Human   222 GVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSS-----------DLQQVGGA 275

  Fly   196 STKLQSLLDLILKYVDDVIAHKVTPDNAVGRQLLDLIHSVPHMTHEQFTQMFNANVRNLLLVITL 260
            |.::|..|..:|:|.:||::.||:.||.|||.|:.|::.||.:..:.|..|.|:|:.:||:|..|
Human   276 SARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYL 340

  Fly   261 SQLIKTQLQLNEKLTFL 277
            :.|.::|:.|||||..|
Human   341 ANLTQSQIALNEKLVNL 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3f1	NP_649489.1	MPN_eIF3f	8..274	CDD:163695	130/272 (48%)
EIF3F	NP_003745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
EIF3F	NP_003745.1	MPN_eIF3f	92..354	CDD:163695	130/272 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147331
Domainoid	1	1.000	139	1.000	Domainoid score	I4803
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2783
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2990
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54712
OrthoDB	1	1.010	-	-		D1038775at2759
OrthoFinder	1	1.000	-	-		FOG0004972
OrthoInspector	1	1.000	-	-		oto88781
orthoMCL	1	0.900	-	-		OOG6_103242
Panther	1	1.100	-	-	LDO	PTHR10540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R381
SonicParanoid	1	1.000	-	-		X3506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940