DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3f1 and mysm1

DIOPT Version :9

Sequence 1:	NP_649489.1	Gene:	eIF3f1 / 40587	FlyBaseID:	FBgn0037270	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_021324132.1	Gene:	mysm1 / 561225	ZFINID:	ZDB-GENE-041014-28	Length:	828	Species:	Danio rerio

Alignment Length:	297	Identity:	57/297 - (19%)
Similarity:	103/297 - (34%)	Gaps:	73/297 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RVHPVVLFQVVDAFERRNADSH----RVIGTLLGSVDKGVVEVTNCFCVP--------HKEHDDQ 61
            |..|..:....:|....:..:|    .|||.|.|:.::....:..|...|        ..|.|..
Zfish   517 RQEPYSVIVCAEALIVMDIHAHVSMGEVIGLLGGTYEEEDKVLKICSAEPCNSLSTGLQCEMDPV 581

  Fly    62 VEAELSYALDMYDLNRKVNSNESVVGWWATGNDVTNHSSVIHEYYARECNNPVHLTVDTSLQGGR 126
            .:.:.|..|.:..|        |||||:             |.:.|.: .||....:||..:
Zfish   582 SQTQASEVLGVKGL--------SVVGWY-------------HSHPAFD-PNPSLRDIDTQAK--- 621

  Fly   127 MGLRAYVCIQLGVPGGKSGCMFTPIPVELTSYEPETFGLK------LLQKTVGVSPAHRPKTVPP 185
              .::|.        .:.|..|  |.:.::.|.|.....:      |:|:..|.|.:|:   .|.
Zfish   622 --YQSYF--------SRGGAPF--IGMIVSPYNPSNSSPQSQSTCLLVQEEPGPSGSHK---FPY 671

  Fly   186 MLDL---AQISEASTKLQSLLDLILKYVDDVIAHKVTPDNAVGR---------QLLDLIHSVPHM 238
            ..::   |:..:.|..::....::.||   .:.|...|.:.:.|         ::|..|.:|...
Zfish   672 QFNMQCSAEPPDWSEVMRRAEWVVFKY---RLCHGSVPMDRLFRRDSSLTCLEKMLLSIRTVLER 733

  Fly   239 THEQFTQMFNANVRNLLLVITLSQLIKTQLQLNEKLT 275
            ..|...:.|...:.:|.....||:...:...|.|..|
Zfish   734 LSEVDIETFLVQLESLFNTHFLSETGSSSTHLYETAT 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3f1	NP_649489.1	MPN_eIF3f	8..274	CDD:163695	56/294 (19%)
mysm1	XP_021324132.1	SANT	107..150	CDD:238096
		SWIRM	331..408	CDD:309539
		MPN_2A_DUB	517..699	CDD:163698	43/224 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900