DRSC/TRiP Functional Genomics Resources

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Protein Alignment smash and LIMD1

DIOPT Version :9

Sequence 1:NP_001246912.1 Gene:smash / 40583 FlyBaseID:FBgn0263346 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_055055.1 Gene:LIMD1 / 8994 HGNCID:6612 Length:676 Species:Homo sapiens


Alignment Length:600 Identity:112/600 - (18%)
Similarity:186/600 - (31%) Gaps:249/600 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1113 LKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLG-------IGNGML--SAFQPPQH 1168
            |::|::.|:..|.:.|     |::..::...|        ||       :|:.:.  .|.:||..
Human    57 LQQQQQQLLQEETLPR-----GSRGPVNGGGR--------LGPQARWEVVGSKLTVDGAAKPPLA 108

  Fly  1169 HQVQMP----------PPHPQQIYANVPQQQQQMVLHA--YHQMDTDYRKSM--SDLNEF----- 1214
            .....|          ||:|.|      :|:.:..||.  :...|...|:|:  |:::.|     
Human   109 ASTGAPGAVTTLAAGQPPYPPQ------EQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGP 167

  Fly  1215 ---SNCLIL---------------------------------------PPTPP---TKPLRAMQL 1234
               .:||..                                       ||.|.   ..||...||
Human   168 CEDPSCLTHGDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQL 232

  Fly  1235 NAN-----------------GHGLEPD---YAVSTRQRQPPAPYGGSLVKIAGA--PMPPRLPGQ 1277
            :.:                 |...|..   ::.::.||..|.....:|...|.|  |:.||.|. 
Human   233 SLSSSRSSEGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPS- 296

  Fly  1278 GYPIQAPTAPAYHHQSAQNLSN----------MSRNTLLALSATPKPKYADGWVQVQQRKSY--D 1330
               :.||.|.:...|.....||          ||:.     :..|:|.:.||      .|||  .
Human   297 ---VSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKP-----NVDPQPWFQDG------PKSYLSS 347

  Fly  1331 SQQTSDAAWLAAQQQKRKSMPDYG--------GALYNNNHWLLQEAEQRRIEQLNRRSIP----A 1383
            |..:|..|.|...||  .::|..|        |.....:...|.......:.:|:.:..|    :
Human   348 SAPSSSPAGLDGSQQ--GAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSS 410

  Fly  1384 SKSMGKPLPDS--------------------------IIQTLTERVQ------------------ 1404
            ..|:|..|.||                          .::.||:|::                  
Human   411 DGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKC 475

  Fly  1405 SKGI-GDRKRFDSNGNY------------SQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVL 1456
            |||: |..:...:.||.            .::.|...|                           
Human   476 SKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFY--------------------------- 513

  Fly  1457 SVSGKKKCS----HCG-DELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTD 1516
            .|:||..|.    :.| .:....|:..|.....||:::|...||..||:|.:|:    :.|:|..
Human   514 FVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICN----ECLDGVP 574

  Fly  1517 VRV-RNHKLHCQNCY 1530
            ..| ..:|::|...|
Human   575 FTVDSENKIYCVRDY 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smashNP_001246912.1 DUF4757 14..152 CDD:292571
LIM <1494..1530 CDD:278823 11/36 (31%)
LIMD1NP_055055.1 Mediates nuclear export 54..134 19/95 (20%)
Atrophin-1 <69..443 CDD:331285 75/409 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..163 14/64 (22%)
Interaction with EGLN1/PHD2 186..260 9/73 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..389 43/216 (20%)
Interaction with RB1. /evidence=ECO:0000269|PubMed:15542589 404..442 6/37 (16%)
Necessary for nuclear localization 472..676 29/148 (20%)
LIM1_Ajuba_like 472..525 CDD:188738 12/79 (15%)
LIM2_Ajuba_like 537..589 CDD:188741 16/55 (29%)
LIM3_Ajuba_like 597..658 CDD:188822
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1704
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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