DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and SCEL

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_659001.2	Gene:	SCEL / 8796	HGNCID:	10573	Length:	688	Species:	Homo sapiens

Alignment Length:	971	Identity:	179/971 - (18%)
Similarity:	294/971 - (30%)	Gaps:	353/971 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 LRDMEFSINEALELALQAIDREATTKPMDKAQHPQKR---EQKEELGGKPEEKEPICEEQHDEES 679
            ||.|..:.||     :::..:..|.|..|..:..::|   :....:..:|||          |:.
Human     6 LRKMSPTGNE-----MKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEE----------EKD 55

  Fly   680 NEQGET----HNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATRIS 740
            ...|..    ||....:..|.:::         :...:|||.:..|:            ...|||
Human    56 ENYGRVVLNRHNSHDALDRKVNER---------DVPKATISRYSSDD------------TLDRIS 99

  Fly   741 HRRSIPSQQTSNSNENNQSTN--------------QTSNSRNQKESSTAATSAANPVPPTTPGEQ 791
            .|........:|:.: ||.||              |...|.|...|:|.|:::|     |||
Human   100 DRNDAAKTYKANTLD-NQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSA-----TTP--- 155

  Fly   792 AEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTES 856
                  |.|..:.::                                          |||||
Human   156 ------VKKKRQSWF------------------------------------------PPPPP--- 169

  Fly   857 PIPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQG--QPEPAQPSPPIKRMNSTK 919
                               |:|..:          |.||||...|  .|.|.:||.|:...|..:
Human   170 -------------------GYNASS----------STGTRRREPGVHPPIPPKPSSPVSSPNQLR 205

  Fly   920 RIKKEL---------RNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYIK 975
            :..:::         ...||:...|.:. |||::           ..:|..||.
Human   206 QDNRQIHPPKPGVYTETNRSAERNIRSQ-DLDNI-----------VKVATSLQR----------- 247

  Fly   976 AGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNES 1040
                  ||.||..|:.:..|.|       .|.::..|:...|.|.
Human   248 ------SDKGEELDNLIKMNKS-------LNRNQGLDSLFRANPK-------------------- 279

  Fly  1041 LLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDK----IREQGEMLRV 1101
                                .|.....|.:.:||        ..|.:..||    |:..|..::|
Human   280 --------------------VEEREKRAKSLESL--------IYMSTRTDKDGKGIQSLGSPIKV 316

  Fly  1102 ERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAFQPP 1166
            .:.     .::.::.|:||   |::|:      ....|:...|..:||.:...:.         |
Human   317 NQR-----TDKNEKGRQNL---ESVAK------VNARMNKTSRRSEDLDNATEVN---------P 358

  Fly  1167 QHHQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRA 1231
            :.|:             |...::.   |....::|.:..|:::......|.:.:.|........:
Human   359 KGHE-------------NTTGKKD---LDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGS 407

  Fly  1232 MQLNANGHGLEPDYAVSTRQRQPPAPYGG----SLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQ 1292
            ..|| |...:.|....||.        ||    ||:|:...........|.........|:.:..
Human   408 KDLN-NFIKVYPGTEKSTE--------GGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKS 463

  Fly  1293 SAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAA---------QQQKR- 1347
            |.|.|......:..|:..|...:..|..::|......::|:..|.|.|..         |.|..
Human   464 SEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLD 528

  Fly  1348 ---KSMPDYGGALYNNNH----WLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQTLTERVQS 1405
               |..|   .||.|.|.    ..|.|......|..|..|...:|..|.  .|:::.|.|....|
Human   529 NLIKVKP---SALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGP--QDTVVYTRTYVENS 588

  Fly  1406 KGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSGKKKCSHCGDE 1470
            |...|..:.:.:|.|.|    .:|....:                      ||..:..|::|...
Human   589 KSPKDGYQENISGKYIQ----TVYSTSDR----------------------SVIERDMCTYCRKP 627

  Fly  1471 LGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCYS 1531
            ||.        ...||::.|.:..|..||||.:|...|.:...|..:.:....:||:.|||
Human   628 LGV--------ETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
SCEL	NP_659001.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..231		33/184 (18%)
		16 X approximate tandem repeats	251..563		71/417 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..373		8/57 (14%)
		LIM	620..678	CDD:214528	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900