DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Ajuba

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_445955.1	Gene:	Ajuba / 85265	RGDID:	620407	Length:	548	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	87/407 - (21%)
Similarity:	131/407 - (32%)	Gaps:	131/407 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1221 PPTPPTKPLRAMQLNANGHGLEPDYAVSTR--QRQPPAPYGGSLVKIAGAPMPPR----LPGQGY 1279
            |..||  |.||:.|..:.   .||:.:.|.  ...|.:.:..|....|..|..||    |.|.|.
  Rat   100 PGGPP--PTRALPLPLSS---PPDFRLETTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGA 159

  Fly  1280 PIQAPTAPAYHHQSAQNLSNMSRN--------TLLALSATPKPK-YADGWVQ------------- 1322
            .....:.|..:..|..::....|:        .|..|..|..|. |:.|.|.
  Rat   160 SGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGLPLTTAPSGYSSGGVPSAYPELHAALDRL 224

  Fly  1323 ----------VQQRKSYDSQQTSDAAWLAA------------QQQKRKSMPDYG----GALYNNN 1361
                      .:.|.||.....|..|...|            .|..|.|:..||    ||.|
  Rat   225 CAHRPVGFGCQESRHSYPPALGSPGALTGAVVGTAGPLERRGTQPGRHSVTGYGDCAAGARY--- 286

  Fly  1362 HWLLQEAEQRRIEQLNRRSIPA----SKSMGKPL---PDSIIQT----LTERVQSKGIGDRKRFD 1415
                    |..:..|.|.::..    :.:.|:||   |..:.::    :.|..:|:......|.|
  Rat   287 --------QDELTALLRLTVATGGREAGARGEPLGIEPSGLEESPGSFVPEASRSRIREPEARED 343

  Fly  1416 --------SNGNYSQVNG----NNIYQQQ-------QQQKNVTNGSSINGNSSQGQEKVLS--VS 1459
                    :.|.|.|.|.    :::|..|       .:........|:||:....::.:.|  ..
  Rat   344 YFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQE 408

  Fly  1460 GKKKCSHCGDELGKLCYYVGCRGAAMIIESLL----LFYHINCFKCCVCHVQLGDGLNGTDVRVR 1520
            ..:||..||.               :|:|.:|    ..||..||:|.||:..| ||:..| |...
  Rat   409 AAEKCCVCGH---------------LILEKILQAMGKSYHPGCFRCIVCNKCL-DGVPFT-VDFS 456

  Fly  1521 N--------HKLHCQNC 1529
            |        ||.:...|
  Rat   457 NQVYCVTDYHKNYAPKC 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	16/44 (36%)
Ajuba	NP_445955.1	PreLIM	1..345		54/260 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		21/86 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	290..298		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..333		5/25 (20%)
		LIM1_Ajuba_like	348..401	CDD:188738	9/52 (17%)
		LIM2_Ajuba_like	413..465	CDD:188741	19/68 (28%)
		LIM3_Ajuba_like	473..534	CDD:188822	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900