DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and RGA2

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	778	Identity:	152/778 - (19%)
Similarity:	252/778 - (32%)	Gaps:	239/778 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   911 PIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYI- 974
            |||.  ..:.:|:.|...|     |....|:....|.:...:...       .|:::|..|:.:
Yeast   147 PIKL--PERSVKRPLSPTR-----INGKSDVSTNNTAISKNLVSS-------NEDQQLTPQVLVS 197

  Fly   975 ----KAGLCDSSDTGESRDSGVSENHSRQSS---------EHYTNSSEE----------NDTQSE 1016
                ::.|.|::|...|:|...:.:|:|..|         ||.:||.||          |....:
Yeast   198 QERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGED 262

  Fly  1017 AT-----------------PPPLPPPPSTAQVGEVIYQNESL-----------LAAQTPLLQTVK 1053
            .|                 .|.:|...|.|.....||..|..           :...||...|.|
Yeast   263 VTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDK 327

  Fly  1054 GNS------AESWTESATAAAAATQSLSEATATANAKMQ--------------------SIEDKI 1092
            ..|      |....|..........:|||||...|...|                    ::|.|.
Yeast   328 ITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKT 392

  Fly  1093 REQGEMLRVERELLHFSQEELKRQRENLVLRENIA-------RRELQHGAKMLMSNNRRSLQDL- 1149
            ......||:. :...||:.:   ..:||:..:.:|       .|.....:|..:.|.:....::
Yeast   393 STSSSTLRLS-DNGSFSRPQ---TADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKTSEML 453

  Fly  1150 -----HHGLGI-------GNGMLSAFQPPQHHQVQMPPPHPQQ----IYANVPQQQQQMVLHAYH 1198
                 ||...|       |.|:.|.....:..:.:..|....|    ||..:||.....|
Yeast   454 DPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTV----- 513

  Fly  1199 QMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLV 1263
             .:.:::|:.|.|...|.                :.|:|      |.|.:.|       ..||..
Yeast   514 -PEFNHKKAQSSLGSISK----------------KQNSN------DTATNRR-------INGSFT 548

  Fly  1264 K------IAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQ 1322
            .      ||....||...|..:...:.::.:.||:|:...::.|.|.||...:| |....|....
Yeast   549 SSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDST-KVDATDESAT 612

  Fly  1323 VQQRKSYDSQQTSDAAWLAAQQ---QKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPAS 1384
            ..::..|.::.|.....|..::   .|:|.:.|.      .|..|.:|.....::.|.|.....|
Yeast   613 SLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDV------ENLRLAKERLLNDVDNLTREKDKQS 671

  Fly  1385 KSMGKPL--PDSIIQTLTERVQSKGIGDRKRFDSNGN--------YSQVNGNNIYQQQQQQKNVT 1439
            .|..:.|  .::|..::|.:..|.. .|||...||.:        :|....:.:...:.||:  :
Yeast   672 ASSRESLEQKENIATSITVKSPSSN-SDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQR--S 733

  Fly  1440 NGSSINGNSSQGQEKV-------------------LSVSGKK-----KCSHC-GDELGKLCYYVG 1479
            ..||..|.::..|:::                   ||.|.|:     ..||. |..|...|.|.
Yeast   734 PNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYE- 797

  Fly  1480 CRGAAMIIESLLLFYHINCFKCCVCHVQLGD-GLN--------GTDVRV--------RNHKLH 1525
             :....||           .:||:..::..| |||        |:...|        :|:.||
Yeast   798 -KSTVPII-----------IRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLH 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	11/49 (22%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	815..1002	CDD:214618	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900