DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and ZYX

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001010972.1	Gene:	ZYX / 7791	HGNCID:	13200	Length:	572	Species:	Homo sapiens

Alignment Length:	767	Identity:	135/767 - (17%)
Similarity:	210/767 - (27%)	Gaps:	294/767 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   778 SAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLM 842
            :|..|.|..:....|..:|...|...|.. |||        ..|..|..|......:.||....|
Human     2 AAPRPSPAISVSVSAPAFYAPQKKFGPVV-APK--------PKVNPFRPGDSEPPPAPGAQRAQM 57

  Fly   843 EPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQ 907
            ....|.|||||.:.|:
Human    58 GRVGEIPPPPPEDFPL------------------------------------------------- 73

  Fly   908 PSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQL 972
            |.||:.                         ||.||.|..|.....|||...:.......||:::
Human    74 PPPPLA-------------------------GDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEI 113

  Fly   973 YIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATP-PPLPPPPSTAQ-VGEVI 1035
            :                                 .|.....:.|..| .|:||||...: |..:.
Human   114 F---------------------------------PSPPPPPEEEGGPEAPIPPPPQPREKVSSID 145

  Fly  1036 YQNESLLAAQTPLLQT--VKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEM 1098
            .:.:||.:....:.:.  .|...:..:.....|...:::|.::..|.
Human   146 LEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAG------------------ 192

  Fly  1099 LRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAF 1163
                                                                     |...|..:
Human   193 ---------------------------------------------------------GTAPLPPW 200

  Fly  1164 QPPQHHQ--VQMPPPHPQQIYANV---PQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPT 1223
            :.|...|  .|:|.|...|...:|   ||.:.|:.||...|
Human   201 KSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQ------------------------ 241

  Fly  1224 PPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPA 1288
              |:|:.               ..:|:.|.|||.......|.  :|:.|:..    |:.:..:|
Human   242 --TQPVS---------------LANTQPRGPPASSPAPAPKF--SPVTPKFT----PVASKFSP- 282

  Fly  1289 YHHQSAQNLSNMSRNTLL----ALSA---TPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQK 1346
                .|...|....|..|    ||||   :|:|   ..:...|||:....|:........||.|.
Human   283 ----GAPGGSGSQPNQKLGHPEALSAGTGSPQP---PSFTYAQQREKPRVQEKQHPVPPPAQNQN 340

  Fly  1347 RKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSI-IQTLTERVQSKGIGD 1410
            :...|...|.|      .|:|.|:  :|||.::.:   :.|..|...:: :..|..|........
Human   341 QVRSPGAPGPL------TLKEVEE--LEQLTQQLM---QDMEHPQRQNVAVNELCGRCHQPLARA 394

  Fly  1411 RKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSGKKKCSHCGDELGKLC 1475
            :....:.|....:.....:|..||              .|||: ..|:.|...|..|..:..:.|
Human   395 QPAVRALGQLFHIACFTCHQCAQQ--------------LQGQQ-FYSLEGAPYCEGCYTDTLEKC 444

  Fly  1476 YYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRV-RNHKLHC 1526
            ...|......::.:....||.:||.|.||    ...|.||...| :.::.||
Human   445 NTCGEPITDRMLRATGKAYHPHCFTCVVC----ARPLEGTSFIVDQANRPHC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	13/34 (38%)
ZYX	NP_001010972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..351		93/573 (16%)
		PAT1	<201..>365	CDD:330585	51/226 (23%)
		LIM1_Zyxin	351..437	CDD:188735	21/111 (19%)
		LIM	444..503	CDD:295319	15/53 (28%)
		LIM3_Zyxin	504..570	CDD:188819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900