Protein Alignment smash and prickle2a

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_068079129.1
• Gene: prickle2a / 777736
• ZFINID: ZDB-GENE-061110-112
• Length: 870
• Species: Danio rerio
• Alignment Length: 687
• Identity: 129/687 - (18%)
• Similarity: 196/687 - (28%)
• Gaps: 267/687 - (38%)

  Fly   749 QTSNSNENNQSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLR 813
            |::.|.:::.|.:...:....|..:...||:.    |||....|||.
Zfish   323 QSARSRQSHHSASVGKDGSKGKGETVRQTSSG----PTTLSGDAEPL------------------ 365

  Fly   814 PVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHN 878
                         .:::...||.:|.     |...|...||.:|        ........||...
Zfish   366 -------------AVQMDLLSVASPA-----PSRTPHRTPTRTP--------SRTSSRSPSLNRE 404

  Fly   879 TDTWSSDNTYETISNGTRRHLQGQPEPAQ------------PSP--PIKRMNSTKRIKKELRNKR 929
            ...|.  |..|..|..::|.....|.|.|            |||  |.|.::|.:...||.....
Zfish   405 QTVWV--NRDEPYSYESQRDSSTSPNPHQLRSQCSIRTAYPPSPNQPPKIVSSQEAWSKEPPGGN 467

  Fly   930 SSFLGIENDGDLDDMETYLELTVAPPPDMAQLL------------QEER----RLEKQLYIKAGL 978
            |.                      .||.||.|.            ||..    :|:.|:
Zfish   468 SK----------------------KPPVMAALRGHSFNENWMHHGQEPEFHPPKLKTQM------ 504

  Fly   979 CDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNESLLA 1043
              |.:...||:||..:..|               ...:..|..:.||...::     :|......
Zfish   505 --SFNEVSSRNSGFLDKRS---------------ISVQGFPREMRPPLLRSR-----HQFRPNFG 547

  Fly  1044 AQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHF 1108
            ..|||.||.:| ||:|...|.|.|.                 .|::...|.|....|       |
Zfish   548 ELTPLEQTPRG-SADSLALSYTTAG-----------------NSLDGTSRRQEHFSR-------F 587

  Fly  1109 SQEELKRQRENLVLRENIARR--------ELQHGAKMLMSNNRRSLQDL---------------- 1149
            |..:|.:..     ..|::.:        .:|..:...:|:..|.|.|:
Zfish   588 SMPDLSKDS-----GVNVSEKGTVGTLNSSVQFRSTESLSSVPRPLADIGMPVRLRYPPPLYWDS 647

  Fly  1150 HHGLGIGN------GMLSAFQPPQHHQVQMPPPHPQQIYA-NVPQQQQQMVLH---AYHQMDTDY 1204
            ..||...:      |:..:....|....|...|.|::..| |.|:||:|...|   .:......|
Zfish   648 PRGLSFEDPVKGRIGLAGSMSCMQDGNAQAMTPRPRRAQAQNSPRQQRQRQRHHRKNHKSQKYQY 712

  Fly  1205 --RKSMSDLNEFSNCLILPPTP---PTKPLR----------AMQLNANGHGLEPDYAVSTRQ--- 1251
              |:|.||     |.|.|....   |..|:.          :.:|:.|..|....|    ||
Zfish   713 RSRRSRSD-----NALHLATEDQSFPGDPIHRFHNDFERPSSSRLSHNLFGANYGY----RQQFF 768

  Fly  1252 ------------RQPPAPYGGSLVKIAGAPMPPR-------------------LPGQGY--PIQ- 1282
                        :.|..|..|..:...|..:...                   |||:|.  |:|
Zfish   769 RPCPRTTSDLTLQDPGGPQIGQYMGRYGEAVEDEDQFCSTCSSSSEASDDDAYLPGEGIPRPVQL 833

  Fly  1283 ------------APTAPAYHHQSAQNLSNMSRNTLLA 1307
                        :||....|.|........|:|.:::
Zfish   834 RYFDNEELRHRYSPTLVGGHTQLHTRKRRKSKNCIIS 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950
		PAT1	<1159..>1335	CDD:401645	43/217 (20%)
		LIM	<1494..1530	CDD:395333
prickle2a	XP_068079129.1	PET_Prickle	22..118	CDD:193602
		LIM1_Prickle	126..184	CDD:188799
		LIM2_Prickle	189..244	CDD:188802
		LIM3_Prickle	249..307	CDD:188804