DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and ZNF185

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_016885310.1	Gene:	ZNF185 / 7739	HGNCID:	12976	Length:	766	Species:	Homo sapiens

Alignment Length:	946	Identity:	178/946 - (18%)
Similarity:	295/946 - (31%)	Gaps:	320/946 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 IDREATTKPMDKAQHPQKREQKEELGGKPEEKEPICEEQHDEESNEQGETHNEGGEMPNKTDKQM 700
            |.|...|||:|.:..||  :|..:..|.|:....:.            .|.|.|...|:
Human    86 IIRGVFTKPIDSSSQPQ--QQFPKANGTPKSAASLV------------RTANAGPPRPS------ 130

  Fly   701 QGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATRISHRRSIPSQQTSNSNENNQSTNQTSN 765
                       ||...|...|.:::|...|           |||..|..|   .|..:......:
Human   131 -----------SSGYKMTTEDYKKLAPYNI-----------RRSSTSGDT---EEEEEEEVVPFS 170

  Fly   766 SRNQKESSTAATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVP-VYENVEIFYSGLE 829
            |..||..|.||:..   :..|.|.|.:.......|:|    .:|......| :.:.||:...
Human   171 SDEQKRRSEAASGV---LRRTAPREHSYVLSAAKKST----GSPTQETQAPFIAKRVEVVEE--- 225

  Fly   830 ISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNG 894
                         :.|.||...||                    :|..:|...:|.:...|.::
Human   226 -------------DGPSEKSQDPP--------------------ALARSTPGSNSADGGRTKAS- 256

  Fly   895 TRRHLQGQPEPAQPSPPIKRMNSTKR---IKKELRNKRSSFLGIENDGDLDDMETYLELTVAPPP 956
              |.:..:..|:.|||...:..|::.   ::.::...|:....:..|         :|...:.|.
Human   257 --RAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD---------VEGMRSSPG 310

  Fly   957 DMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPP 1021
            :..:.....|.|::.|           .||......:.:.:|.|::....:.....|.|.
Human   311 NKDKEAPCSRELQRDL-----------AGEEAFRAPNTDAARSSAQLSDGNVGSGATGSR----- 359

  Fly  1022 LPPPPSTAQVGEVIYQNESLLAAQT--PLLQTVKGNSAESWTESATAAAAATQSLSEATATANAK 1084
               |...|.| ::..:...|.||.:  ..|:...|:||.|.:.....||.::.:.|.:...|:.|
Human   360 ---PEGLAAV-DIGSERGRLCAAASFASFLEDQDGHSANSQSCKPRPAAISSSATSVSAVPADRK 420

  Fly  1085 MQSIEDKIREQGEMLRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDL 1149
            ..|..                   :||:.|                         ::.:.:|.|
Human   421 SNSTA-------------------AQEDAK-------------------------ADPKGALAD- 440

  Fly  1150 HHGLGIGNGMLSAFQ----PPQHHQVQMPPPHPQQIYANVPQQQ------QQMV------LHAYH 1198
            :.|..:...:..|:|    .|:..|.....|..|....:.|::|      :|:|      .....
Human   441 YEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSRRVP 505

  Fly  1199 QMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRA--MQLNANGH-G---LEPDYAVSTR------- 1250
            |.|:..:|             :||.|...|.:.  .:..|.|| |   |.|..:|.|.
Human   506 QPDSSPKK-------------IPPLPCGGPGQGSIRRDKAGGHIGDCLLTPGASVLTDFEGKDVA 557

  Fly  1251 -------QRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLAL 1308
                   |.:|.||.||.     |.|        ..|.|.|..|
Human   558 TKVGEAWQDRPGAPRGGQ-----GDP--------AVPTQQPADP--------------------- 588

  Fly  1309 SATPKPKYA-DGWVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRR 1372
             :||:.:.: .|..|..:|:|..|:..|.::.:....                   :...:||..
Human   589 -STPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVT-------------------VTATSEQPH 633

  Fly  1373 IEQLNRRSIPASKSMGKPLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKN 1437
            |      .|||..|           .|.....:|||...|.:        ||.:.:...:.....
Human   634 I------YIPAPAS-----------ELDSSSTTKGILFVKEY--------VNASEVSSGKPVSAR 673

  Fly  1438 VTNGSSINGNSSQGQEKVLSVSGKKKCS---HCGDELGKLCYYVG-----CRGAAMIIESLLLFY 1494
            .:|.|||        |...::..|..|.   :.....|.:|.|..     |  ..:.:|.|.:..
Human   674 YSNVSSI--------EDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDC--PKITLEHLGICC 728

  Fly  1495 HINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
            |..||||.:|...:||.|:  .:.:....:||..||
Human   729 HEYCFKCGICSKPMGDLLD--QIFIHRDTIHCGKCY 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	11/35 (31%)
ZNF185	XP_016885310.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900