DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Fblim1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006539276.1	Gene:	Fblim1 / 74202	MGIID:	1921452	Length:	397	Species:	Mus musculus

Alignment Length:	400	Identity:	80/400 - (20%)
Similarity:	130/400 - (32%)	Gaps:	140/400 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1155 IGNGMLSAFQPPQHHQVQM---PPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSN 1216
            :.||..| ..||..::..:   |||.|...|..:|:::..::         ..:..:|||.:
Mouse   101 LSNGGCS-LPPPSLNEEDLDLPPPPPPPSAYLPLPEEEPPVL---------PGKSLISDLEQ--- 152

  Fly  1217 CLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPI 1281
             |.|||.||..|.:|....::.|. .|.:|:.:.:..||.|           ..|..||.:  .:
Mouse   153 -LHLPPPPPPPPPQAPSKGSSVHP-PPGHAIPSEEELPPPP-----------EEPVTLPER--EV 202

  Fly  1282 QAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQK 1346
            ........|                      ||        |..|:            ||.:..|
Mouse   203 STDVCGFCH----------------------KP--------VSPRE------------LAVEAMK 225

  Fly  1347 RKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQTLTERVQSKGIGDR 1411
            |:    |....:.......|.|.||..::           .|:||.:...|...|:.
Mouse   226 RQ----YHAQCFTCRTCRRQLAGQRFYQK-----------DGRPLCEPCYQDTLEKC-------- 267

  Fly  1412 KRFDSNGNYSQVNGNNIYQQQQQQKN------VTNGSSINGNS----SQGQEKVLSVSGKK---K 1463
                  |...:|...::.:...:..:      ||....|:..|    ||.|...::...:|   .
Mouse   268 ------GKCGEVVQEHVIRALGKAFHPPCFTCVTCARCISDESFALDSQNQVYCVADFYRKFAPV 326

  Fly  1464 CSHCGDEL----GKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKL 1524
            ||.|.:.:    ||..:.:.|.|..         :|.||::|..|.|.|  .:..||
Mouse   327 CSICENPIIPRDGKDAFKIECMGRN---------FHENCYRCEDCSVLL--SVEPTD-------- 372

  Fly  1525 HCQNCYSSDD 1534
              |.||..:|
Mouse   373 --QGCYPLND 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
Fblim1	XP_006539276.1	LIM	<203..260	CDD:351770	17/113 (15%)
		LIM2_FBLP-1	267..319	CDD:188758	9/65 (14%)
		LIM3_Zyxin_like	327..388	CDD:188743	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900