DRSC/TRiP Functional Genomics Resources

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Protein Alignment smash and TRIP6

DIOPT Version :9

Sequence 1:NP_001246912.1 Gene:smash / 40583 FlyBaseID:FBgn0263346 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_003293.2 Gene:TRIP6 / 7205 HGNCID:12311 Length:476 Species:Homo sapiens


Alignment Length:330 Identity:74/330 - (22%)
Similarity:114/330 - (34%) Gaps:99/330 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   581 PSPLPPSPALPAVQQSLQQPTVAQVP-AQAVNQAA-APPLRDMEFSINEALELALQAIDREATTK 643
            |:.|||           :||..|:.| .:|:.:.. .||         .|...|||         
Human     4 PTWLPP-----------KQPEPARAPQGRAIPRGTPGPP---------PAHGAALQ--------- 39

  Fly   644 PMDKAQH-PQKREQKEELGGKPEEKEPICEEQHDEESNEQGETHNEGGEMPNKTDKQMQGGREPI 707
            |..:... |...||..:..|.||::.|.....|....:.||...:.||..|...|.::       
Human    40 PHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEI------- 97

  Fly   708 YENVSSTISMHEVDNEQIATMTITTQTQATRISHRRSI-----PSQQTSNSNENNQSTNQTSNSR 767
             :.:|||::  |::.         .:..|:|...|::.     |:.:|.:...|..|....|...
Human    98 -DLLSSTLA--ELNG---------GRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYG 150

  Fly   768 NQKESS--TAATSA----------ANPV----PPTTPGEQAE-----PYYQVPKATE---PYYDA 808
            ....:|  ||:|.|          |.||    ||.....||.     |::.:|...|   |.|.:
Human   151 GPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRS 215

  Fly   809 PKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGN 873
            .:...|            |.:.....|..|.|.....:..|       .:||.:..:||||.|..
Human   216 QREPGP------------GAKEEAAGVSGPAGRGRGGEHGP-------QVPLSQPPEDELDRLTK 261

  Fly   874 SLGHN 878
            .|.|:
Human   262 KLVHD 266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smashNP_001246912.1 DUF4757 14..152 CDD:292571
LIM <1494..1530 CDD:278823
TRIP6NP_003293.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 29/117 (25%)
Atrophin-1 <8..251 CDD:331285 65/309 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..253 33/172 (19%)
LIM1_TRIP6 279..332 CDD:188736
LIM 339..398 CDD:295319
LIM3_Zyxin_like 399..461 CDD:188743
Interaction with MAGI1 and PTPN13. /evidence=ECO:0000269|PubMed:19017743 469..476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1704
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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